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Serum and tissue miRNAs: potential biomarkers for the diagnosis of cervical cancer.
Farzanehpour, Mahdieh; Mozhgani, Sayed-Hamidreza; Jalilvand, Somayeh; Faghihloo, Ebrahim; Akhavan, Setareh; Salimi, Vahid; Azad, Talat Mokhtari.
Afiliación
  • Farzanehpour M; Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, 1471613151, Iran.
  • Mozhgani SH; Department of Microbiology, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran.
  • Jalilvand S; Non-communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran.
  • Faghihloo E; Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, 1471613151, Iran.
  • Akhavan S; Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Salimi V; Department of Gynecology Oncology, Imam Khomeini Hospital Complex, Valiasr Hospital, Tehran University of Medical Sciences, Tehran, Iran.
  • Azad TM; Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, 1471613151, Iran.
Virol J ; 16(1): 116, 2019 10 07.
Article en En | MEDLINE | ID: mdl-31590680
BACKGROUND: Finding new biomarkers for the early detection of cervical cancer is an essential requirement in this field. In this study, we aimed to evaluate the expression level of potential biomarkers in progression of cervical cancer in patients with cervical cancer compared to normal subjects. METHODS: The expression levels of tissue and serum miRNAs, including miR-9, miR-192 and miR-205, were investigated in 36 normal, 18 precancer, and 18 cervical cancer samples using real-time polymerase chain reaction. RESULTS: The results showed the higher significant expressions of miR-9, miR-192 and miR-205 in the tissue of cancer samples than those in the normal samples. Moreover, the miR-192 and miR-205 expression were significantly increased in the cancer group in comparison with the precancer group. Examination of serum samples revealed the increase in the expression level in the cancer groups than in the normal samples, for miR-9, miR-192 and miR-205 and the expressions of miR-9, miR-192 and miR-205 were significantly up-regulated in the precancer group in comparison with the normal group. Also the expression of miR-205 was remarkably increased in the cancer group in comparison with the precancer group. The receiver operating characteristic (ROC) analyses showed the highest area under the curve value for miR-192. CONCLUSIONS: Given the increased expression level of miR-192 in cancer and in precancerous tissue and serum compared with the normal tissue and serum validated by analysing the ROC curve, miR-192 can be used as potential biomarker for the early detection of cervical cancer.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Biomarcadores de Tumor / Neoplasias del Cuello Uterino / MicroARNs / Detección Precoz del Cáncer Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies / Screening_studies Límite: Adult / Aged / Aged80 / Female / Humans / Middle aged Idioma: En Revista: Virol J Asunto de la revista: VIROLOGIA Año: 2019 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Biomarcadores de Tumor / Neoplasias del Cuello Uterino / MicroARNs / Detección Precoz del Cáncer Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies / Screening_studies Límite: Adult / Aged / Aged80 / Female / Humans / Middle aged Idioma: En Revista: Virol J Asunto de la revista: VIROLOGIA Año: 2019 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Reino Unido