Oral administration of hydroxylated-graphene quantum dots induces intestinal injury accompanying the loss of intestinal stem cells and proliferative progenitor cells.

Yu, Lan; Tian, Xin; Gao, Dexuan; Lang, Yue; Zhang, Xiang-Xiang; Yang, Chen; Gu, Meng-Meng; Shi, Jianming; Zhou, Ping-Kun; Shang, Zeng-Fu

Yu, Lan; Tian, Xin; Gao, Dexuan; Lang, Yue; Zhang, Xiang-Xiang; Yang, Chen; Gu, Meng-Meng; Shi, Jianming; Zhou, Ping-Kun; Shang, Zeng-Fu.

Afiliación

Yu L; State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Medical College of Soochow University; Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou, China.
Tian X; Suzhou Digestive Diseases and Nutrition Research Center, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, China.
Gao D; State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Medical College of Soochow University; Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou, China.
Lang Y; Department of Urology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China.
Zhang XX; State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Medical College of Soochow University; Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou, China.
Yang C; State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Medical College of Soochow University; Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou, China.
Gu MM; The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, China.
Shi J; The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, China.
Zhou PK; Suzhou Digestive Diseases and Nutrition Research Center, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, China.
Shang ZF; State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Medical College of Soochow University; Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou, China.

Nanotoxicology ; 13(10): 1409-1421, 2019 12.

Article en En | MEDLINE | ID: mdl-31589482

Asunto(s)

Apoptosis/efectos de los fármacos; Proliferación Celular/efectos de los fármacos; Grafito/toxicidad; Mucosa Intestinal/efectos de los fármacos; Puntos Cuánticos/toxicidad; Células Madre/efectos de los fármacos; Administración Oral; Animales; Apoptosis/genética; Proliferación Celular/genética; Daño del ADN; Grafito/química; Hidroxilación; Mucosa Intestinal/patología; Intestino Delgado/efectos de los fármacos; Intestino Delgado/patología; Masculino; Ratones; Ratones Endogámicos C57BL; Estrés Oxidativo/efectos de los fármacos; Permeabilidad; Puntos Cuánticos/química; Células Madre/patología; Propiedades de Superficie; Proteína p53 Supresora de Tumor/genética

Palabras clave

DNA damage; Graphene quantum dots; intestinal injury; intestinal stem cells; p53

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células Madre / Apoptosis / Puntos Cuánticos / Proliferación Celular / Grafito / Mucosa Intestinal Límite: Animals Idioma: En Revista: Nanotoxicology Asunto de la revista: TOXICOLOGIA Año: 2019 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google