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Neonatal Immune Activation May Provoke Long-term Depressive Attributes.
Schelder-Marzzani, Simone H; Dias, Paula; Freiberger, Viviane; Ventura, Letícia; Silva, Bruna B; Dutra, Matheus L; Bobinski, Franciane; Schlindwein, Aline D; Cassol, Omar J; Comim, Clarissa M.
Afiliación
  • Schelder-Marzzani SH; Research Group in Neurodevelopment of Childhood and Adolescence, Laboratory of Experimental Neuroscience, Postgraduate Program in Health Sciences, University of South Santa Catarina, Avenida Pedra Branca, 25, Pedra Branca, 88137-270 Palhoca, SC, Brazil.
  • Dias P; Research Group in Neurodevelopment of Childhood and Adolescence, Laboratory of Experimental Neuroscience, Postgraduate Program in Health Sciences, University of South Santa Catarina, Avenida Pedra Branca, 25, Pedra Branca, 88137-270 Palhoca, SC, Brazil.
  • Freiberger V; Research Group in Neurodevelopment of Childhood and Adolescence, Laboratory of Experimental Neuroscience, Postgraduate Program in Health Sciences, University of South Santa Catarina, Avenida Pedra Branca, 25, Pedra Branca, 88137-270 Palhoca, SC, Brazil.
  • Ventura L; Research Group in Neurodevelopment of Childhood and Adolescence, Laboratory of Experimental Neuroscience, Postgraduate Program in Health Sciences, University of South Santa Catarina, Avenida Pedra Branca, 25, Pedra Branca, 88137-270 Palhoca, SC, Brazil.
  • Silva BB; Research Group on Allergy, Inflammation and Infectious Diseases, Laboratory of Experimental Neuroscience, Postgraduate Program in Health Sciences, University of South Santa Catarina, Avenida Pedra Branca, 25, Pedra Branca, 88137-270 Palhoca, SC, Brazil.
  • Dutra ML; Research Group in Neurodevelopment of Childhood and Adolescence, Laboratory of Experimental Neuroscience, Postgraduate Program in Health Sciences, University of South Santa Catarina, Avenida Pedra Branca, 25, Pedra Branca, 88137-270 Palhoca, SC, Brazil.
  • Bobinski F; Research Group of Neuroscience and Pharmacology, Laboratory of Experimental Neuroscience, Postgraduate Program in Health Sciences, University of South Santa Catarina, Avenida Pedra Branca, 25, Pedra Branca, 88137-270 Palhoca, SC, Brazil.
  • Schlindwein AD; Research Group of Neuroscience and Pharmacology, Laboratory of Experimental Neuroscience, Postgraduate Program in Health Sciences, University of South Santa Catarina, Avenida Pedra Branca, 25, Pedra Branca, 88137-270 Palhoca, SC, Brazil.
  • Cassol OJ; Research Group in Neurodevelopment of Childhood and Adolescence, Laboratory of Experimental Neuroscience, Postgraduate Program in Health Sciences, University of South Santa Catarina, Avenida Pedra Branca, 25, Pedra Branca, 88137-270 Palhoca, SC, Brazil.
  • Comim CM; Research Group in Neurodevelopment of Childhood and Adolescence, Laboratory of Experimental Neuroscience, Postgraduate Program in Health Sciences, University of South Santa Catarina, Avenida Pedra Branca, 25, Pedra Branca, 88137-270 Palhoca, SC, Brazil.
Curr Neurovasc Res ; 16(4): 358-364, 2019.
Article en En | MEDLINE | ID: mdl-31589124
BACKGROUND: Studies have shown the relationship between neuroinflammation and depressive- like parameters. However, research still has not been carried out to evaluate neuroinflammation in the neonatal period and psychiatric disorders in adulthood. OBJECTIVE: To verify the association between neonatal immune activation and depressive-like parameters in adulthood using an animal model. METHODS: Two days old C57BL/6 animals were exposed to lipopolysaccharides (LPS) or phosphate- buffered saline (PBS). When the animals were 46 days old, they received PBS or Imipramine at 14 days. At 60 days, the consumption of sucrose; immobility time; adrenal gland and the hippocampus weight; levels of plasma corticosterone and hippocampal Brain-derived neurotrophic factor (BDNF) were evaluated. RESULTS: It was observed that the animals exposed to LPS in the neonatal period and evaluated in adulthood decreased the consumption of sucrose and had reducted hippocampus weight. Also, the exposed animals presented an increase of immobility time, adrenal gland weight and plasma levels of corticosteroids. The use of imipramine did not only modify the decreased hippocampal weight. On the other hand, there were no alterations in the BDNF levels in the hippocampus with or without the use of imipramine. CONCLUSION: These results suggest that neonatal immune activation may be associated with depressive- like parameters in adulthood. It is believed that endotoxemia may trigger physiological and behavioral alterations, increasing vulnerability for the development of depression in adulthood.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tiempo / Depresión / Hipocampo / Imipramina Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Curr Neurovasc Res Asunto de la revista: ANGIOLOGIA / NEUROLOGIA Año: 2019 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Emiratos Árabes Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tiempo / Depresión / Hipocampo / Imipramina Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Curr Neurovasc Res Asunto de la revista: ANGIOLOGIA / NEUROLOGIA Año: 2019 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Emiratos Árabes Unidos