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Malignant development in patients with oral potentially malignant disorders detected through nationwide screening: Outcomes of 5-year follow-up at a single hospital.
Chiang, Wei-Fan; Liu, Shyun-Yeu; Lin, Jen-Fen; Chiu, Sheng-Fu; Gou, Shin-Bin; Chiou, Chang-Ta; Chang, Chi-Hua.
Afiliación
  • Chiang WF; Department of Oral and Maxillofacial Surgery, Chi-Mei Medical Center, Liouying, Taiwan.
  • Liu SY; School of Dentistry, National Yang-Ming University, Taipei, Taiwan.
  • Lin JF; Department of Oral and Maxillofacial Surgery, Chi-Mei Medical Center, Yongkang, Taiwan.
  • Chiu SF; Cancer Center, Chi-Mei Medical Center, Liouying, Taiwan.
  • Gou SB; Department of Oral and Maxillofacial Surgery, Chi-Mei Medical Center, Liouying, Taiwan.
  • Chiou CT; Department of Oral and Maxillofacial Surgery, Chi-Mei Medical Center, Liouying, Taiwan.
  • Chang CH; Department of Oral and Maxillofacial Surgery, An-Nan Hospital, Tainan, Taiwan.
Head Neck ; 42(1): 67-76, 2020 01.
Article en En | MEDLINE | ID: mdl-31589002
BACKGROUND: Although survival rate and quality of life are improved if patients with oral carcinoma can be detected early, however, such lesions are usually asymptomatic; therefore, it is hard to raise awareness. Screening has proved to be cost-effective for early detection. METHODS: Sixty-two patients with oral carcinomas and 555 patients with oral potentially malignant disorders (OPMDs) who were detected through screening were examined the relationship between clinicopathological features and follow-up outcomes. RESULTS: The 5-year cumulative cancer-free interval rate was 94.1%, and the annual malignant transformation rate was 1.16%. The rate of interval carcinoma development from Candida hyperplasia, oral submucous fibrosis, homogeneous leukoplakia, non-homogenous leukoplakia, and verrucous hyperplasia, was 13.6%, 5.7%, 4.6%, 12.1%, and 21.3%, respectively. Significant independent risk factors for interval carcinoma development were heavy betel quid chewing, verrucous hyperplasia, and surgery refusal. CONCLUSIONS: Well-designed risk assessment, treatment, and surveillance program could lead to earlier cancer detection and thereby reduce mortality and morbidity.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Lesiones Precancerosas / Calidad de Vida Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Aspecto: Patient_preference Límite: Humans Idioma: En Revista: Head Neck Asunto de la revista: NEOPLASIAS Año: 2020 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Lesiones Precancerosas / Calidad de Vida Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Aspecto: Patient_preference Límite: Humans Idioma: En Revista: Head Neck Asunto de la revista: NEOPLASIAS Año: 2020 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Estados Unidos