Cytochrome P450-Mediated Metabolic Characterization of a Mono-Carbonyl Curcumin Analog WZ35.

Wang, Guangbao; Li, Yinghui; Sun, Wei; Wang, Zhe; Chen, Daoxing; Shu, Sheng; Jin, Jiayi; Mahoo, Janeth; Pan, Liuliu; Hu, Guoxin; Liu, Zhiguo; Zhang, Xiaodan

Wang, Guangbao; Li, Yinghui; Sun, Wei; Wang, Zhe; Chen, Daoxing; Shu, Sheng; Jin, Jiayi; Mahoo, Janeth; Pan, Liuliu; Hu, Guoxin; Liu, Zhiguo; Zhang, Xiaodan.

Afiliación

Wang G; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China.
Li Y; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China.
Sun W; Department of Pharmacy, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Wang Z; Department of Pharmacy, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Chen D; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China.
Shu S; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China.
Jin J; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China.
Mahoo J; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China.
Pan L; Department of Obstetrics and Gynecology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Hu G; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China.
Liu Z; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China.
Zhang X; Department of Pharmacy, The Seventh People's Hospital of Wenzhou, Wenzhou, China, ha.daybreak@163.com.

Pharmacology ; 105(1-2): 79-89, 2020.

Article en En | MEDLINE | ID: mdl-31587004

Asunto(s)

Antineoplásicos/farmacocinética; Curcumina/análogos & derivados; Curcumina/farmacocinética; Inhibidores Enzimáticos del Citocromo P-450/farmacocinética; Animales; Antineoplásicos/sangre; Disponibilidad Biológica; Inhibidores Enzimáticos del Citocromo P-450/sangre; Sistema Enzimático del Citocromo P-450/metabolismo; Masculino; Simulación del Acoplamiento Molecular; Ratas Sprague-Dawley

Palabras clave

Curcumin; Cytochrome P450; Pharmacokinetic; Time-dependent inhibition; Ultraperformance liquid chromatography-tandem mass spectrometry

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Curcumina / Inhibidores Enzimáticos del Citocromo P-450 / Antineoplásicos Límite: Animals Idioma: En Revista: Pharmacology Año: 2020 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza

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