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Tracking white matter degeneration in asymptomatic and symptomatic MAPT mutation carriers.
Chen, Qin; Boeve, Bradley F; Schwarz, Christopher G; Reid, Robert; Tosakulwong, Nirubol; Lesnick, Timothy G; Bove, Jessica; Brannelly, Patrick; Brushaber, Danielle; Coppola, Giovanni; Dheel, Christina; Dickerson, Bradford C; Dickinson, Susan; Faber, Kelley; Fields, Julie; Fong, Jamie; Foroud, Tatiana; Forsberg, Leah; Gavrilova, Ralitza H; Gearhart, Debra; Ghoshal, Nupur; Goldman, Jill; Graff-Radford, Jonathan; Graff-Radford, Neill R; Grossman, Murray; Haley, Dana; Heuer, Hilary W; Hsiung, Ging-Yuek R; Huey, Edward; Irwin, David J; Jack, Clifford R; Jones, David T; Jones, Lynne; Karydas, Anna M; Knopman, David S; Kornak, John; Kramer, Joel; Kremers, Walter; Kukull, Walter A; Lapid, Maria; Lucente, Diane; Lungu, Codrin; Mackenzie, Ian R A; Manoochehri, Masood; McGinnis, Scott; Miller, Bruce L; Pearlman, Rodney; Petrucelli, Leonard; Potter, Madeline; Rademakers, Rosa.
Afiliación
  • Chen Q; Department of Neurology, West China Hospital of Sichuan University, Chengdu, Sichuan, China; Department of Radiology, Mayo Clinic, Rochester, MN, USA.
  • Boeve BF; Department of Neurology, Mayo Clinic, Rochester, MN, USA.
  • Schwarz CG; Department of Radiology, Mayo Clinic, Rochester, MN, USA.
  • Reid R; Department of Radiology, Mayo Clinic, Rochester, MN, USA.
  • Tosakulwong N; Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
  • Lesnick TG; Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
  • Bove J; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Brannelly P; Tau Consortium, Rainwater Charitable Foundation, Fort Worth, TX, USA.
  • Brushaber D; Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
  • Coppola G; Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, CA, USA.
  • Dheel C; Department of Neurology, Mayo Clinic, Rochester, MN, USA.
  • Dickerson BC; Department of Neurology, Frontotemporal Disorders Unit, Massachusetts General Hospital, Harvard University, Boston, MA, USA.
  • Dickinson S; Association for Frontotemporal Degeneration, Radnor, PA, USA.
  • Faber K; National Cell Repository for Alzheimer's Disease (NCRAD), Indiana University, Indianapolis, IN, USA.
  • Fields J; Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA.
  • Fong J; Department of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco, CA, USA.
  • Foroud T; National Cell Repository for Alzheimer's Disease (NCRAD), Indiana University, Indianapolis, IN, USA.
  • Forsberg L; Department of Neurology, Mayo Clinic, Rochester, MN, USA.
  • Gavrilova RH; Department of Neurology, Mayo Clinic, Rochester, MN, USA.
  • Gearhart D; Department of Neurology, Mayo Clinic, Rochester, MN, USA.
  • Ghoshal N; Departments of Neurology and Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
  • Goldman J; Department of Neurology, Columbia University, New York, NY, USA.
  • Graff-Radford J; Department of Neurology, Mayo Clinic, Rochester, MN, USA.
  • Graff-Radford NR; Department of Neurology, Mayo Clinic, Jacksonville, FL, USA.
  • Grossman M; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Haley D; Department of Neurology, Mayo Clinic, Jacksonville, FL, USA.
  • Heuer HW; Department of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco, CA, USA.
  • Hsiung GR; Division of Neurology, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
  • Huey E; Department of Neurology, Columbia University, New York, NY, USA.
  • Irwin DJ; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Jack CR; Department of Radiology, Mayo Clinic, Rochester, MN, USA.
  • Jones DT; Department of Neurology, Mayo Clinic, Rochester, MN, USA.
  • Jones L; Department of Radiology, Washington University School of Medicine, Washington University, St. Louis, MO, USA.
  • Karydas AM; Department of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco, CA, USA.
  • Knopman DS; Department of Neurology, Mayo Clinic, Rochester, MN, USA.
  • Kornak J; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA.
  • Kramer J; Department of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco, CA, USA.
  • Kremers W; Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
  • Kukull WA; National Alzheimer Coordinating Center (NACC), University of Washington, Seattle, WA, USA.
  • Lapid M; Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA.
  • Lucente D; Department of Neurology, Frontotemporal Disorders Unit, Massachusetts General Hospital, Harvard University, Boston, MA, USA.
  • Lungu C; National Institute of Neurological Disorders and Stroke (NINDS), Bethesda, MD, USA.
  • Mackenzie IRA; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
  • Manoochehri M; Department of Neurology, Columbia University, New York, NY, USA.
  • McGinnis S; Department of Neurology, Frontotemporal Disorders Unit, Massachusetts General Hospital, Harvard University, Boston, MA, USA.
  • Miller BL; Department of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco, CA, USA.
  • Pearlman R; Bluefield Project, San Francisco, CA, USA.
  • Petrucelli L; Department of Neurosciences, Mayo Clinic, Jacksonville, FL, USA.
  • Potter M; National Cell Repository for Alzheimer's Disease (NCRAD), Indiana University, Indianapolis, IN, USA.
  • Rademakers R; Department of Neurosciences, Mayo Clinic, Jacksonville, FL, USA.
Neurobiol Aging ; 83: 54-62, 2019 11.
Article en En | MEDLINE | ID: mdl-31585367
Our aim was to investigate the patterns and trajectories of white matter (WM) diffusion abnormalities in microtubule-associated protein tau (MAPT) mutations carriers. We studied 22 MAPT mutation carriers (12 asymptomatic, 10 symptomatic) and 20 noncarriers from 8 families, who underwent diffusion tensor imaging (DTI) and a subset (10 asymptomatic, 6 symptomatic MAPT mutation carriers, and 10 noncarriers) were followed annually (median = 4 years). Cross-sectional and longitudinal changes in mean diffusivity (MD) and fractional anisotropy were analyzed. Asymptomatic MAPT mutation carriers had higher MD in entorhinal WM, which propagated to the limbic tracts and frontotemporal projections in the symptomatic stage compared with noncarriers. Reduced fractional anisotropy and increased MD in the entorhinal WM were associated with the proximity to estimated and actual age of symptom onset. The annualized change of entorhinal MD on serial DTI was accelerated in MAPT mutation carriers compared with noncarriers. Entorhinal WM diffusion abnormalities precede the symptom onset and track with disease progression in MAPT mutation carriers. Our cross-sectional and longitudinal data showed a potential clinical utility for DTI to track neurodegenerative disease progression for MAPT mutation carriers in clinical trials.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas tau / Demencia Frontotemporal / Sustancia Blanca / Mutación Tipo de estudio: Diagnostic_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Neurobiol Aging Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas tau / Demencia Frontotemporal / Sustancia Blanca / Mutación Tipo de estudio: Diagnostic_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Neurobiol Aging Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos