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An Allosteric Anti-tryptase Antibody for the Treatment of Mast Cell-Mediated Severe Asthma.
Maun, Henry R; Jackman, Janet K; Choy, David F; Loyet, Kelly M; Staton, Tracy L; Jia, Guiquan; Dressen, Amy; Hackney, Jason A; Bremer, Meire; Walters, Benjamin T; Vij, Rajesh; Chen, Xiaocheng; Trivedi, Neil N; Morando, Ashley; Lipari, Michael T; Franke, Yvonne; Wu, Xiumin; Zhang, Juan; Liu, John; Wu, Ping; Chang, Diana; Orozco, Luz D; Christensen, Erin; Wong, Manda; Corpuz, Racquel; Hang, Julie Q; Lutman, Jeff; Sukumaran, Siddharth; Wu, Yan; Ubhayakar, Savita; Liang, Xiaorong; Schwartz, Lawrence B; Babina, Magda; Woodruff, Prescott G; Fahy, John V; Ahuja, Rahul; Caughey, George H; Kusi, Aija; Dennis, Mark S; Eigenbrot, Charles; Kirchhofer, Daniel; Austin, Cary D; Wu, Lawren C; Koerber, James T; Lee, Wyne P; Yaspan, Brian L; Alatsis, Kathila R; Arron, Joseph R; Lazarus, Robert A; Yi, Tangsheng.
Afiliación
  • Maun HR; Department of Early Discovery Biochemistry, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Jackman JK; Department of Immunology Discovery, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Choy DF; Department of Biomarker Discovery OMNI, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Loyet KM; Department of Biochemical and Cellular Pharmacology, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Staton TL; Department of OMNI Biomarker Development, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Jia G; Department of Biomarker Discovery OMNI, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Dressen A; Department of Human Genetics, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Hackney JA; Department of Bioinformatics, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Bremer M; Department of OMNI Biomarker Development, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Walters BT; Department of Biochemical and Cellular Pharmacology, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Vij R; Department of Antibody Engineering, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Chen X; Department of Antibody Engineering, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Trivedi NN; Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA; Veterans Affairs Medical Center, San Francisco, CA 94121, USA.
  • Morando A; Department of Biochemical and Cellular Pharmacology, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Lipari MT; Department of Early Discovery Biochemistry, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Franke Y; Depratment of Biomolecular Resources, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Wu X; Department of Translational Immunology, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Zhang J; Department of Translational Immunology, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Liu J; Department of Translational Immunology, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Wu P; Department of Structural Biology, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Chang D; Department of Human Genetics, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Orozco LD; Department of Bioinformatics, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Christensen E; Department of Protein Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Wong M; Department of Structural Biology, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Corpuz R; Department of Structural Biology, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Hang JQ; Department of Protein Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Lutman J; Department of Preclinical and Translational Pharmacokinetics, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Sukumaran S; Department of Preclinical and Translational Pharmacokinetics, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Wu Y; Department of Antibody Engineering, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Ubhayakar S; Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Liang X; Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Schwartz LB; Department of Internal Medicine, Division of Rheumatology, Allergy and Immunology, Virginia Commonwealth University, Richmond, VA 23298, USA.
  • Babina M; Department of Dermatology and Allergy, Charité Universitätsmedizin Berlin, Berlin, Germany.
  • Woodruff PG; Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.
  • Fahy JV; Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.
  • Ahuja R; Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA; Veterans Affairs Medical Center, San Francisco, CA 94121, USA.
  • Caughey GH; Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA; Veterans Affairs Medical Center, San Francisco, CA 94121, USA.
  • Kusi A; Department of Safety Assessment, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Dennis MS; Department of Antibody Engineering, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Eigenbrot C; Department of Structural Biology, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Kirchhofer D; Department of Early Discovery Biochemistry, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Austin CD; Department of Pathology, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Wu LC; Department of Immunology Discovery, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Koerber JT; Department of Antibody Engineering, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Lee WP; Department of Translational Immunology, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Yaspan BL; Department of Human Genetics, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Alatsis KR; Department of Safety Assessment, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Arron JR; Department of Immunology Discovery, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA. Electronic address: arron.joseph@gene.com.
  • Lazarus RA; Department of Early Discovery Biochemistry, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA. Electronic address: lazarus.bob@gene.com.
  • Yi T; Department of Immunology Discovery, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA. Electronic address: yi.tangsheng@gene.com.
Cell ; 179(2): 417-431.e19, 2019 Oct 03.
Article en En | MEDLINE | ID: mdl-31585081
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Asma / Triptasas / Anticuerpos Monoclonales Humanizados / Mastocitos Límite: Adolescent / Animals / Female / Humans / Male Idioma: En Revista: Cell Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Asma / Triptasas / Anticuerpos Monoclonales Humanizados / Mastocitos Límite: Adolescent / Animals / Female / Humans / Male Idioma: En Revista: Cell Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos