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Effect of Xueniao Capsule on Escherichia coli-Induced Acute Pyelonephritis Rats by 1H NMR-Based Metabolomic Approach.
Hao, Xuliang; He, Pan; Ni, Yan; Yao, Jing; Yang, Yankun; Liu, Cong; Chen, Lei.
Afiliación
  • Hao X; Shanxi Institute of Traditional Chinese Medicine, No. 46 Bingzhou West Street, Taiyuan 030012, China.
  • He P; Shanxi Institute of Traditional Chinese Medicine, No. 46 Bingzhou West Street, Taiyuan 030012, China.
  • Ni Y; Shanxi Institute of Traditional Chinese Medicine, No. 46 Bingzhou West Street, Taiyuan 030012, China.
  • Yao J; Shanxi Institute of Traditional Chinese Medicine, No. 46 Bingzhou West Street, Taiyuan 030012, China.
  • Yang Y; Shanxi Institute of Traditional Chinese Medicine, No. 46 Bingzhou West Street, Taiyuan 030012, China.
  • Liu C; Shanxi Institute of Traditional Chinese Medicine, No. 46 Bingzhou West Street, Taiyuan 030012, China.
  • Chen L; Shanxi Institute of Medicine and Life Science, No. 61 Pingyang Road, Taiyuan 030006, China.
Evid Based Complement Alternat Med ; 2019: 6723956, 2019.
Article en En | MEDLINE | ID: mdl-31565063
Xueniao capsule, one of the famous traditional Chinese medicine (TCM) formulas, has been proved to be effective for treating acute pyelonephritis (APN) in the clinic. However, the probable mechanisms are still unclear. This study was aimed at investigating the therapeutic effect and action mechanism of Xueniao capsule on acute pyelonephritis rats. Chemical analysis of Xueniao capsule and four different extracts was conducted by HPLC and GC-MS. 21 compounds were identified in the Xueniao capsule, and obvious chemical difference was also revealed among the different extracts by chemical analysis. Metabolomics, combined with bacteriological examination, traditional histopathology, and biochemical parameters, was used to evaluate the effects of Xueniao capsule and four different extracts. After treatment with Xueniao capsule, the bacterial count of urine was decreased and the renal lesions of APN rats were ameliorated by histopathology inspection. Levels of Scr and Ucr, IL-1α, IL-1ß, IL-6, IL-10, CXCL-2, and MCP-1 were decreased significantly, and the reserving effect of Xueniao capsule was superior to the different extracts and norfloxacin. 16 endogenous metabolites related to APN model were revealed, and 12 of them could be reversed by the Xueniao capsule. 1H NMR metabolomic results demonstrated that the formula of Xueniao capsule played the best therapeutic role on APN through regulating energy metabolism and alterations of osmotic pressure. The effect of Xueniao capsule on the APN was the synergistic actions of multiple components, which need to be further investigated in future studies.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Evid Based Complement Alternat Med Año: 2019 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Evid Based Complement Alternat Med Año: 2019 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos