Your browser doesn't support javascript.
loading
Staging of Schizophrenia With the Use of PANSS: An International Multi-Center Study.
Fountoulakis, Konstantinos N; Dragioti, Elena; Theofilidis, Antonis T; Wikilund, Tobias; Atmatzidis, Xenofon; Nimatoudis, Ioannis; Thys, Erik; Wampers, Martien; Hranov, Luchezar; Hristova, Trayana; Aptalidis, Daniil; Milev, Roumen; Iftene, Felicia; Spaniel, Filip; Knytl, Pavel; Furstova, Petra; From, Tiina; Karlsson, Henry; Walta, Maija; Salokangas, Raimo K R; Azorin, Jean-Michel; Bouniard, Justine; Montant, Julie; Juckel, Georg; Haussleiter, Ida S; Douzenis, Athanasios; Michopoulos, Ioannis; Ferentinos, Panagiotis; Smyrnis, Nikolaos; Mantonakis, Leonidas; Nemes, Zsófia; Gonda, Xenia; Vajda, Dora; Juhasz, Anita; Shrivastava, Amresh; Waddington, John; Pompili, Maurizio; Comparelli, Anna; Corigliano, Valentina; Rancans, Elmars; Navickas, Alvydas; Hilbig, Jan; Bukelskis, Laurynas; Injac Stevovic, Lidija; Vodopic, Sanja; Esan, Oluyomi; Oladele, Oluremi; Osunbote, Christopher; Rybakowski, Janusz Κ; Wojciak, Pawel.
Afiliación
  • Fountoulakis KN; 3rd Department of Psychiatry, Faculty of Medicine, School of Health Sciences, Aristotle University of Thessaloniki, Greece.
  • Dragioti E; Department of Medical and Health Sciences (IMH), Faculty of Health Sciences, Linköping University, Linköping, Sweden.
  • Theofilidis AT; Hallunda Psychiatric Outpatient Clinic, Stockholm Psychiatric Southwest Clinic, Karolinska Huddinge University Hospital, Sweden.
  • Wikilund T; 3rd Department of Psychiatry, Faculty of Medicine, School of Health Sciences, Aristotle University of Thessaloniki, Greece.
  • Atmatzidis X; Department of Medical and Health Sciences (IMH), Faculty of Health Sciences, Linköping University, Linköping, Sweden.
  • Nimatoudis I; Hallunda Psychiatric Outpatient Clinic, Stockholm Psychiatric Southwest Clinic, Karolinska Huddinge University Hospital, Sweden.
  • Thys E; Department of Medical and Health Sciences (IMH), Faculty of Health Sciences, Linköping University, Linköping, Sweden.
  • Wampers M; Hallunda Psychiatric Outpatient Clinic, Stockholm Psychiatric Southwest Clinic, Karolinska Huddinge University Hospital, Sweden.
  • Hranov L; 3rd Department of Psychiatry, Faculty of Medicine, School of Health Sciences, Aristotle University of Thessaloniki, Greece.
  • Hristova T; University Psychiatric Centre KU Leuven, Kortenberg and Department of Neurosciences KU, Leuven, Belgium.
  • Aptalidis D; University Psychiatric Centre KU Leuven, Kortenberg and Department of Neurosciences KU, Leuven, Belgium.
  • Milev R; University Multiprofile Hospital for Active Treatment in Neurology and Psychiatry "Sveti Naum", Sofia, Bulgaria.
  • Iftene F; University Multiprofile Hospital for Active Treatment in Neurology and Psychiatry "Sveti Naum", Sofia, Bulgaria.
  • Spaniel F; University Multiprofile Hospital for Active Treatment in Neurology and Psychiatry "Sveti Naum", Sofia, Bulgaria.
  • Knytl P; Department of Psychiatry, Queen's University, Providence Care Hospital, Kingston, Ontario, Canada.
  • Furstova P; Department of Psychiatry, Queen's University, Providence Care Hospital, Kingston, Ontario, Canada.
  • From T; National Institute of Mental Health, Klecany, Czech Republic.
  • Karlsson H; National Institute of Mental Health, Klecany, Czech Republic.
  • Walta M; National Institute of Mental Health, Klecany, Czech Republic.
  • Salokangas RKR; Department of Psychiatry, University of Turku, Turku, Finland.
  • Azorin JM; Department of Psychiatry, University of Turku, Turku, Finland.
  • Bouniard J; Department of Psychiatry, University of Turku, Turku, Finland.
  • Montant J; Department of Psychiatry, University of Turku, Turku, Finland.
  • Juckel G; Department of Psychiatry, Sainte Marguerite University Hospital, Marseille, France.
  • Haussleiter IS; Timone Institute of Neuroscience, CNRS and Aix-Marseille University, Marseille, France.
  • Douzenis A; Department of Psychiatry, Sainte Marguerite University Hospital, Marseille, France.
  • Michopoulos I; Timone Institute of Neuroscience, CNRS and Aix-Marseille University, Marseille, France.
  • Ferentinos P; Department of Psychiatry, Sainte Marguerite University Hospital, Marseille, France.
  • Smyrnis N; Timone Institute of Neuroscience, CNRS and Aix-Marseille University, Marseille, France.
  • Mantonakis L; Department of Psychiatry, Ruhr University Bochum, LWL-University Hospital, Bochum, Germany.
  • Nemes Z; Department of Psychiatry, Ruhr University Bochum, LWL-University Hospital, Bochum, Germany.
  • Gonda X; 2nd Department of Psychiatry, National and Kapodistrian University of Athens, Athens, Greece.
  • Vajda D; 2nd Department of Psychiatry, National and Kapodistrian University of Athens, Athens, Greece.
  • Juhasz A; 2nd Department of Psychiatry, National and Kapodistrian University of Athens, Athens, Greece.
  • Shrivastava A; Department of Psychiatry, National and Kapodistrian University of Athens School of Medicine, Eginition Hospital, Athens, Greece.
  • Waddington J; Department of Psychiatry, National and Kapodistrian University of Athens School of Medicine, Eginition Hospital, Athens, Greece.
  • Pompili M; Nyíro Gyula Hospital, Budapest, Hungary.
  • Comparelli A; Department of Psychiatry and Psychotherapy, Semmelweis University, Budapest, Hungary.
  • Corigliano V; Department of Psychiatry and Psychotherapy, Semmelweis University, Budapest, Hungary.
  • Rancans E; Department of Psychiatry and Psychotherapy, Semmelweis University, Budapest, Hungary.
  • Navickas A; Western University, London Ontario, Canada.
  • Hilbig J; Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland.
  • Bukelskis L; Department of Neurosciences, Mental Health and Sensory Organs, Suicide Prevention Center, Sant'Andrea Hospital, Sapienza University of Rome, Rome, Italy.
  • Injac Stevovic L; Department of Neurosciences, Mental Health and Sensory Organs, Suicide Prevention Center, Sant'Andrea Hospital, Sapienza University of Rome, Rome, Italy.
  • Vodopic S; Department of Neurosciences, Mental Health and Sensory Organs, Suicide Prevention Center, Sant'Andrea Hospital, Sapienza University of Rome, Rome, Italy.
  • Esan O; Department of Psychiatry and Narcology, Riga Stradins University, Riga, Latvia.
  • Oladele O; Clinic of Psychiatric, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.
  • Osunbote C; Psychosocial Rehabilitation Department of the Vilnius Mental Health Center, Department for Psychosis Treatment of the Vilnius Mental Health Center, Vilnius, Lithuania.
  • Rybakowski JΚ; Clinic of Psychiatric, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.
  • Wojciak P; Psychosocial Rehabilitation Department of the Vilnius Mental Health Center, Department for Psychosis Treatment of the Vilnius Mental Health Center, Vilnius, Lithuania.
Int J Neuropsychopharmacol ; 22(11): 681-697, 2019 11 01.
Article en En | MEDLINE | ID: mdl-31563956
INTRODUCTION: A specific clinically relevant staging model for schizophrenia has not yet been developed. The aim of the current study was to evaluate the factor structure of the PANSS and develop such a staging method. METHODS: Twenty-nine centers from 25 countries contributed 2358 patients aged 37.21 ± 11.87 years with schizophrenia. Analysis of covariance, Exploratory Factor Analysis, Discriminant Function Analysis, and inspection of resultant plots were performed. RESULTS: Exploratory Factor Analysis returned 5 factors explaining 59% of the variance (positive, negative, excitement/hostility, depression/anxiety, and neurocognition). The staging model included 4 main stages with substages that were predominantly characterized by a single domain of symptoms (stage 1: positive; stages 2a and 2b: excitement/hostility; stage 3a and 3b: depression/anxiety; stage 4a and 4b: neurocognition). There were no differences between sexes. The Discriminant Function Analysis developed an algorithm that correctly classified >85% of patients. DISCUSSION: This study elaborates a 5-factor solution and a clinical staging method for patients with schizophrenia. It is the largest study to address these issues among patients who are more likely to remain affiliated with mental health services for prolonged periods of time.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Escalas de Valoración Psiquiátrica / Esquizofrenia / Progresión de la Enfermedad Tipo de estudio: Clinical_trials / Prognostic_studies Límite: Adult / Female / Humans / Male / Middle aged País/Región como asunto: Africa / Europa Idioma: En Revista: Int J Neuropsychopharmacol Asunto de la revista: NEUROLOGIA / PSICOFARMACOLOGIA Año: 2019 Tipo del documento: Article País de afiliación: Grecia Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Escalas de Valoración Psiquiátrica / Esquizofrenia / Progresión de la Enfermedad Tipo de estudio: Clinical_trials / Prognostic_studies Límite: Adult / Female / Humans / Male / Middle aged País/Región como asunto: Africa / Europa Idioma: En Revista: Int J Neuropsychopharmacol Asunto de la revista: NEUROLOGIA / PSICOFARMACOLOGIA Año: 2019 Tipo del documento: Article País de afiliación: Grecia Pais de publicación: Reino Unido