Design and development of molecular hybrids of 2-pyridylpiperazine and 5-phenyl-1,3,4-oxadiazoles as potential multifunctional agents to treat Alzheimer's disease.

Tripathi, Avanish; Choubey, Priyanka Kumari; Sharma, Piyoosh; Seth, Ankit; Tripathi, Prabhash Nath; Tripathi, Manish Kumar; Prajapati, Santosh Kumar; Krishnamurthy, Sairam; Shrivastava, Sushant Kumar

Tripathi, Avanish; Choubey, Priyanka Kumari; Sharma, Piyoosh; Seth, Ankit; Tripathi, Prabhash Nath; Tripathi, Manish Kumar; Prajapati, Santosh Kumar; Krishnamurthy, Sairam; Shrivastava, Sushant Kumar.

Afiliación

Tripathi A; Department of Pharmaceutical Engineering & Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi, 221005, India.
Choubey PK; Department of Pharmaceutical Engineering & Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi, 221005, India.
Sharma P; Department of Pharmaceutical Engineering & Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi, 221005, India.
Seth A; Department of Pharmaceutical Engineering & Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi, 221005, India.
Tripathi PN; Department of Pharmaceutical Engineering & Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi, 221005, India.
Tripathi MK; Department of Pharmaceutical Engineering & Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi, 221005, India.
Prajapati SK; Department of Pharmaceutical Engineering & Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi, 221005, India.
Krishnamurthy S; Department of Pharmaceutical Engineering & Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi, 221005, India.
Shrivastava SK; Department of Pharmaceutical Engineering & Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi, 221005, India. Electronic address: skshrivastava.phe@itbhu.ac.in.

Eur J Med Chem ; 183: 111707, 2019 Dec 01.

Article en En | MEDLINE | ID: mdl-31561043

Asunto(s)

Enfermedad de Alzheimer/tratamiento farmacológico; Fármacos Neuroprotectores/química; Oxadiazoles/química; Piperazinas/química; Piridinas/química; Acetilcolinesterasa/metabolismo; Enfermedad de Alzheimer/psicología; Secretasas de la Proteína Precursora del Amiloide/antagonistas & inhibidores; Secretasas de la Proteína Precursora del Amiloide/metabolismo; Animales; Antioxidantes/química; Antioxidantes/farmacología; Barrera Hematoencefálica/metabolismo; Butirilcolinesterasa/metabolismo; Inhibidores de la Colinesterasa/química; Inhibidores de la Colinesterasa/farmacocinética; Disfunción Cognitiva/tratamiento farmacológico; Femenino; Humanos; Cinética; Simulación del Acoplamiento Molecular; Fármacos Neuroprotectores/farmacocinética; Oxadiazoles/farmacocinética; Piperazinas/farmacocinética; Agregado de Proteínas; Piridinas/farmacocinética; Ratas Wistar; Relación Estructura-Actividad

Palabras clave

Acetylcholinesterase (AChE); Alzheimer's disease; Aß aggregation; Molecular hybridization; Multi-functional agents; ß-Secretase-1 (BACE-1)

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oxadiazoles / Piperazinas / Piridinas / Fármacos Neuroprotectores / Enfermedad de Alzheimer Límite: Animals / Female / Humans Idioma: En Revista: Eur J Med Chem Año: 2019 Tipo del documento: Article País de afiliación: India Pais de publicación: Francia

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