The transient expression of CHIKV VLP in large stirred tank bioreactors.

Chen, Peifeng; Demirji, Jacob; Ivleva, Vera B; Horwitz, Joe; Schwartz, Richard; Arnold, Frank

Chen, Peifeng; Demirji, Jacob; Ivleva, Vera B; Horwitz, Joe; Schwartz, Richard; Arnold, Frank.

Afiliación

Chen P; Vaccine Production Program, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9 West Watkins Mill Rd, Gaithersburg, MD, 20878, USA. Peifeng.chen@nih.gov.
Demirji J; Vaccine Production Program, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9 West Watkins Mill Rd, Gaithersburg, MD, 20878, USA.
Ivleva VB; Vaccine Production Program, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9 West Watkins Mill Rd, Gaithersburg, MD, 20878, USA.
Horwitz J; Amicus Therapeutics, 1 Cedarbrook Dr, Cranbury, NJ, 08512, USA.
Schwartz R; CRISPR Therapeutics, 610 Main St, Cambridge, MA, 02139, USA.
Arnold F; Tunnell Consulting, 900 E. 8th Ave, King of Prussia, PA, 19406, USA.

Cytotechnology ; 71(6): 1079-1093, 2019 Dec.

Article en En | MEDLINE | ID: mdl-31560090

Palabras clave

Chikungunya virus; DNA and PEI; Large stirred tank bioreactor; Scale-up challenge; Shear stress; Transient gene expression; Virus-like particle vaccine; ambr® 15 bioreactor; pH

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Cytotechnology Asunto de la revista: BIOTECNOLOGIA / GENETICA Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos

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