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NaCl Nanoparticles as a Cancer Therapeutic.
Jiang, Wen; Yin, Lei; Chen, Hongmin; Paschall, Amy Victoria; Zhang, Liuyang; Fu, Wenyan; Zhang, Weizhong; Todd, Trever; Yu, Kevin Shengyang; Zhou, Shiyi; Zhen, Zipeng; Butler, Michael; Yao, Li; Zhang, Feng; Shen, Ye; Li, Zibo; Yin, Amelia; Yin, Hang; Wang, Xianqiao; Avci, Fikri Y; Yu, Xiaozhong; Xie, Jin.
Afiliación
  • Jiang W; Department of Chemistry, University of Georgia, Athens, GA, 30602, USA.
  • Yin L; Department of Environmental Health Science, University of Georgia, Athens, GA, 30602, USA.
  • Chen H; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, Fujian, 361102, China.
  • Paschall AV; Center for Molecular Medicine, Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA, 30602, USA.
  • Zhang L; State Key Laboratory for Manufacturing Systems Engineering, Xi'an Jiaotong University, Xi'an, Shanxi, 710049, China.
  • Fu W; Center for Molecular Medicine, Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA, 30602, USA.
  • Zhang W; Department of Chemistry, University of Georgia, Athens, GA, 30602, USA.
  • Todd T; Department of Chemistry, University of Georgia, Athens, GA, 30602, USA.
  • Yu KS; Department of Environmental Health Science, University of Georgia, Athens, GA, 30602, USA.
  • Zhou S; Department of Chemistry, University of Georgia, Athens, GA, 30602, USA.
  • Zhen Z; Department of Chemistry, University of Georgia, Athens, GA, 30602, USA.
  • Butler M; Department of Chemistry, University of Georgia, Athens, GA, 30602, USA.
  • Yao L; Science Education, Howard Hughes Medical Institute, Chevy Chase, MD, 20815, USA.
  • Zhang F; Department of Epidemiology and Biostatistics, University of Georgia, Athens, GA, 30602, USA.
  • Shen Y; Department of Epidemiology and Biostatistics, University of Georgia, Athens, GA, 30602, USA.
  • Li Z; Department of Radiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
  • Yin A; Center for Molecular Medicine, Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA, 30602, USA.
  • Yin H; Center for Molecular Medicine, Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA, 30602, USA.
  • Wang X; College of Engineering, University of Georgia, Athens, GA, 30602, USA.
  • Avci FY; Center for Molecular Medicine, Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA, 30602, USA.
  • Yu X; Department of Environmental Health Science, University of Georgia, Athens, GA, 30602, USA.
  • Xie J; Department of Chemistry, University of Georgia, Athens, GA, 30602, USA.
Adv Mater ; 31(46): e1904058, 2019 Nov.
Article en En | MEDLINE | ID: mdl-31553099
Many inorganic nanoparticles are prepared and their behaviors in living systems are investigated. Yet, common electrolytes such as NaCl are left out of this campaign. The underlying assumption is that electrolyte nanoparticles will quickly dissolve in water and behave similarly as their constituent salts. Herein, this preconception is challenged. The study shows that NaCl nanoparticles (SCNPs) but not salts are highly toxic to cancer cells. This is because SCNPs enter cells through endocytosis, bypassing cell regulations on ion transport. When dissolved inside cancer cells, SCNPs cause a surge of osmolarity and rapid cell lysis. Interestingly, normal cells are much more resistant to the treatment due to their relatively low sodium levels. Unlike conventional chemotherapeutics, SCNPs cause immunogenic cell death or ICD. In vivo studies show that SCNPs not only kill cancer cells, but also boost an anticancer immunity. The discovery opens up a new perspective on nanoparticle-based therapeutics.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cloruro de Sodio / Nanopartículas / Nanomedicina Teranóstica / Neoplasias Límite: Humans Idioma: En Revista: Adv Mater Asunto de la revista: BIOFISICA / QUIMICA Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Alemania
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cloruro de Sodio / Nanopartículas / Nanomedicina Teranóstica / Neoplasias Límite: Humans Idioma: En Revista: Adv Mater Asunto de la revista: BIOFISICA / QUIMICA Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Alemania