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The association between polymorphisms in tankyrase gene and telomere length in omethoate-exposed workers.
Yang, Yongli; Tan, Jiebing; Duan, Xiaoran; Zhang, Hui; Feng, Xiaolei; Wang, Tuanwei; Wang, Pengpeng; Ding, Mingcui; Liu, Suxiang; Li, Lei; Liang, Haiyong; Yao, Wu; Wang, Wei; Zhou, Xiaoshan.
Afiliación
  • Yang Y; Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, 450001, Henan, China.
  • Tan J; Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, 450001, Henan, China.
  • Duan X; Department of Occupational Health and Occupational Diseases, College of Public Health, Zhengzhou University, Zhengzhou, 450001, Henan, China.
  • Zhang H; Department of Occupational Health and Occupational Diseases, College of Public Health, Zhengzhou University, Zhengzhou, 450001, Henan, China.
  • Feng X; Department of Occupational Health and Occupational Diseases, College of Public Health, Zhengzhou University, Zhengzhou, 450001, Henan, China.
  • Wang T; Department of Occupational Health and Occupational Diseases, College of Public Health, Zhengzhou University, Zhengzhou, 450001, Henan, China.
  • Wang P; Department of Occupational Health and Occupational Diseases, College of Public Health, Zhengzhou University, Zhengzhou, 450001, Henan, China.
  • Ding M; Department of Occupational Health and Occupational Diseases, College of Public Health, Zhengzhou University, Zhengzhou, 450001, Henan, China.
  • Liu S; Clinical Department, Zhengzhou Institute of Occupational Health, Zhengzhou, 450052, Henan, China.
  • Li L; Clinical Department, Zhengzhou Institute of Occupational Health, Zhengzhou, 450052, Henan, China.
  • Liang H; BioMiao Biological Technology Co., Ltd, Beijing, 100044, Beijing, China.
  • Yao W; Department of Occupational Health and Occupational Diseases, College of Public Health, Zhengzhou University, Zhengzhou, 450001, Henan, China.
  • Wang W; Department of Occupational Health and Occupational Diseases, College of Public Health, Zhengzhou University, Zhengzhou, 450001, Henan, China.
  • Zhou X; Department of Occupational Health and Occupational Diseases, College of Public Health, Zhengzhou University, Zhengzhou, 450001, Henan, China. Electronic address: zhouxiaoshan2017@126.com.
Chemosphere ; 238: 124863, 2020 Jan.
Article en En | MEDLINE | ID: mdl-31551201
Peripheral blood leukocyte telomere length in omethoate-exposed workers is related to environmental exposure and single nucleotide polymorphisms (SNPs) in genes including p21, GSTM1, miR-145, etc. However, the roles of SNPs in tankyrase (TNKS) gene in telomere length are still unknown. The aim of this study was to explore the association between SNPs in TNKS gene and telomere length in omethoate-exposed workers. Telomere length in peripheral blood leukocyte DNA from 180 omethoate-exposed workers and 115 healthy controls was measured using Real-time quantitative polymerase chain reaction (PCR). Genotyping of the selected functional and susceptible SNPs was performed by the flight mass spectrometry based on PCR and single-base extension. The analysis of covariance was performed to find effects of SNPs on telomere length. Generalized linear models were used to analyze the environment, gene, and interaction on telomere length. The results showed that telomere length in the CG + CC genotypes in rs1055328 in TNKS gene was significantly longer than that in the wild homozygous GG genotype both in exposure group (P = 0.017) and in control group (P = 0.038) after adjusting the covariates. The variables kept in the generalized linear models included omethoate-exposure (ß = 0.580, P = 0.001) and rs1055328 (CG + CC) in TNKS gene (ß = 0.339, P = 0.002). The study suggests that the prolongation of telomere length is associated with omethoate-exposure and the CG + CC genotypes in rs1055328 in TNKS gene.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Exposición Profesional / Telómero / Tanquirasas / Dimetoato / Homeostasis del Telómero Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Chemosphere Año: 2020 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Exposición Profesional / Telómero / Tanquirasas / Dimetoato / Homeostasis del Telómero Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Chemosphere Año: 2020 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido