JNK-IN-8, a c-Jun N-terminal kinase inhibitor, improves functional recovery through suppressing neuroinflammation in ischemic stroke.

Zheng, Jianjian; Dai, Qinxue; Han, Kunyuan; Hong, Wandong; Jia, Danyun; Mo, Yunchang; Lv, Ya; Tang, Hongli; Fu, Hongxing; Geng, Wujun

Zheng, Jianjian; Dai, Qinxue; Han, Kunyuan; Hong, Wandong; Jia, Danyun; Mo, Yunchang; Lv, Ya; Tang, Hongli; Fu, Hongxing; Geng, Wujun.

Afiliación

Zheng J; Key Laboratory of Diagnosis and Treatment of Severe Hepato-Pancreatic Diseases, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People's Republic of China.
Dai Q; Department of Anesthesiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People's Republic of China.
Han K; Department of Anesthesiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People's Republic of China.
Hong W; Department of Gastroenterology and Hepatology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People's Republic of China.
Jia D; Department of Anesthesiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People's Republic of China.
Mo Y; Department of Anesthesiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People's Republic of China.
Lv Y; Department of Anesthesiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People's Republic of China.
Tang H; Department of Anesthesiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People's Republic of China.
Fu H; School of Pharmaceutical, Wenzhou Medical University, Wenzhou, Zhejiang, People's Republic of China.
Geng W; Department of Anesthesiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People's Republic of China.

J Cell Physiol ; 235(3): 2792-2799, 2020 03.

Article en En | MEDLINE | ID: mdl-31541462

Asunto(s)

Lesiones Traumáticas del Encéfalo/tratamiento farmacológico; Hipoxia-Isquemia Encefálica/tratamiento farmacológico; Accidente Cerebrovascular Isquémico/tratamiento farmacológico; Proteínas Quinasas JNK Activadas por Mitógenos/antagonistas & inhibidores; Fármacos Neuroprotectores/farmacología; Animales; Antiinflamatorios/farmacología; Apoptosis/efectos de los fármacos; Lesiones Traumáticas del Encéfalo/patología; Células Cultivadas; Hipoxia-Isquemia Encefálica/patología; Inflamación/tratamiento farmacológico; Interleucina-1beta/análisis; Interleucina-6/análisis; Accidente Cerebrovascular Isquémico/patología; Proteínas Quinasas JNK Activadas por Mitógenos/metabolismo; Aprendizaje/efectos de los fármacos; Masculino; Microglía/metabolismo; Arteria Cerebral Media/patología; Neuroprotección/efectos de los fármacos; Ratas; Ratas Sprague-Dawley; Corteza Sensoriomotora/efectos de los fármacos; Corteza Sensoriomotora/patología; Factor de Transcripción ReIA/metabolismo; Factor de Necrosis Tumoral alfa/análisis

Palabras clave

JNK; JNK-IN-8; NF-κB; ischemia brain injury; neuroinflammation

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fármacos Neuroprotectores / Hipoxia-Isquemia Encefálica / Proteínas Quinasas JNK Activadas por Mitógenos / Lesiones Traumáticas del Encéfalo / Accidente Cerebrovascular Isquémico Límite: Animals Idioma: En Revista: J Cell Physiol Año: 2020 Tipo del documento: Article Pais de publicación: Estados Unidos

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