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Exploring the Pathological Mechanism of Bladder Cancer Based on Tumor Mutational Burden Analysis.
Ma, Yao; Feng, Xiao-Fei; Yang, Wan-Xia; You, Chong-Ge.
Afiliación
  • Ma Y; Laboratory Medicine Center, Lanzhou University Second Hospital, Lanzhou 730030, China.
  • Feng XF; Department of Orthopaedics, Lanzhou University Second Hospital, Lanzhou 730030, China.
  • Yang WX; Key Laboratory of Osteoarthritis of Gansu Province, Lanzhou University Second Hospital, No. 82 Cuiyingmen, Lanzhou, Gansu 730030, China.
  • You CG; Laboratory Medicine Center, Lanzhou University Second Hospital, Lanzhou 730030, China.
Biomed Res Int ; 2019: 1093815, 2019.
Article en En | MEDLINE | ID: mdl-31534952
Although immunotherapy has progressed in the treatment of bladder cancer, some patients still have poor prognosis. New therapeutic targets are eager to be discovered to improve the outcomes of bladder cancer. With the development of high-throughput sequencing and tumor profiling, potential tumor biomarkers were identified. Through the interpretation of related data from the Cancer Genome Atlas database (TCGA), some key genes have been discovered to drive the development and prognosis of urinary bladder neoplasm. On account of the success of immunotherapy in many cancer types, we established the relationship between tumor mutation burden and immune microenvironment of bladder cancer and found the changes of several immune cells in this disease. Based on the understanding of the bladder tumor genome and immune environment, this study is supposed to provide new therapies for the treatment of bladder neoplasm.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Vejiga Urinaria / Biomarcadores de Tumor / Secuenciación de Nucleótidos de Alto Rendimiento / Microambiente Tumoral / Mutación Límite: Female / Humans / Male Idioma: En Revista: Biomed Res Int Año: 2019 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Vejiga Urinaria / Biomarcadores de Tumor / Secuenciación de Nucleótidos de Alto Rendimiento / Microambiente Tumoral / Mutación Límite: Female / Humans / Male Idioma: En Revista: Biomed Res Int Año: 2019 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos