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Immune checkpoint blockade in small cell lung cancer.
Tay, Rebecca Y; Heigener, David; Reck, Martin; Califano, Raffaele.
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  • Tay RY; Department of Medical Oncology, The Christie NHS Foundation Trust, Manchester, United Kingdom.
  • Heigener D; Helios Klinik Schleswig, Dept. of Pulmonology, Schleswig, Germany.
  • Reck M; Lung Clinic Grosshansdorf, Airway Research Center North, German Center of Lung Research, Grosshansdorf, Germany.
  • Califano R; Department of Medical Oncology, The Christie NHS Foundation Trust, Manchester, United Kingdom; Department of Medical Oncology, Manchester University NHS Foundation Trust, Manchester, United Kingdom; Division of Cancer Sciences, University of Manchester, Manchester, United Kingdom. Electronic address
Lung Cancer ; 137: 31-37, 2019 11.
Article en En | MEDLINE | ID: mdl-31525648
Despite the highly immunogenic potential of small cell lung cancer (SCLC), progress in evaluating the therapeutic value of immune checkpoint agents has lagged behind that of non-small cell lung cancer. Results from a number of phase I-III clinical trials that specifically address the use of anti-PD-1, anti-PD-L1 and anti-CTLA-4 agents in SCLC have now been reported. This review will focus on the available evidence for immune checkpoint blockade in SCLC and review current biomarker strategies with the aim of providing perspective and interpretation of this data for clinical practice.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma Pulmonar de Células Pequeñas / Antígeno B7-H1 / Antígeno CTLA-4 / Antineoplásicos Inmunológicos / Inmunoterapia / Neoplasias Pulmonares Límite: Animals / Humans Idioma: En Revista: Lung Cancer Asunto de la revista: NEOPLASIAS Año: 2019 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Irlanda
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma Pulmonar de Células Pequeñas / Antígeno B7-H1 / Antígeno CTLA-4 / Antineoplásicos Inmunológicos / Inmunoterapia / Neoplasias Pulmonares Límite: Animals / Humans Idioma: En Revista: Lung Cancer Asunto de la revista: NEOPLASIAS Año: 2019 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Irlanda