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Community Curation and Expert Curation of Human Long Noncoding RNAs with LncRNAWiki and LncBook.
Ma, Lina; Cao, Jiabao; Liu, Lin; Li, Zhao; Shireen, Huma; Pervaiz, Nashaiman; Batool, Fatima; Raza, Rabail Z; Zou, Dong; Bao, Yiming; Abbasi, Amir A; Zhang, Zhang.
Afiliación
  • Ma L; BIG Data Center, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.
  • Cao J; CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.
  • Liu L; BIG Data Center, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.
  • Li Z; CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.
  • Shireen H; University of Chinese Academy of Sciences, Beijing, China.
  • Pervaiz N; BIG Data Center, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.
  • Batool F; CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.
  • Raza RZ; University of Chinese Academy of Sciences, Beijing, China.
  • Zou D; BIG Data Center, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.
  • Bao Y; CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.
  • Abbasi AA; University of Chinese Academy of Sciences, Beijing, China.
  • Zhang Z; National Center for Bioinformatics, Programme of Comparative and Evolutionary Genomics, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.
Curr Protoc Bioinformatics ; 67(1): e82, 2019 09.
Article en En | MEDLINE | ID: mdl-31524988
In recent years, the number of human long noncoding RNAs (lncRNAs) that have been identified has increased exponentially. However, these lncRNAs are poorly annotated compared to protein-coding genes, posing great challenges for a better understanding of their functional significance and elucidating their complex functioning molecular mechanisms. Here we employ both community and expert curation to yield a comprehensive collection of human lncRNAs and their annotations. Specifically, LncRNAWiki (http://lncrna.big.ac.cn/index.php/Main_Page) uses a wiki-based community curation model, thus showing great promise in dealing with the flood of biological knowledge, while LncBook (http://bigd.big.ac.cn/lncbook) is an expert curation-based database that provides a complement to LncRNAWiki. LncBook features a comprehensive collection of human lncRNAs and a systematic curation of lncRNAs by multi-omics data integration, functional annotation, and disease association. These protocols provide step-by-step instructions on how to browse and search a specific lncRNA and how to obtain a range of related information including expression, methylation, variation, function, and disease association. © 2019 by John Wiley & Sons, Inc.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Investigación Participativa Basada en la Comunidad / Anotación de Secuencia Molecular Límite: Humans Idioma: En Revista: Curr Protoc Bioinformatics Año: 2019 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Investigación Participativa Basada en la Comunidad / Anotación de Secuencia Molecular Límite: Humans Idioma: En Revista: Curr Protoc Bioinformatics Año: 2019 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos