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Varicella outbreak trends in school settings during the voluntary single-dose vaccine era from 2006 to 2017 in Shanghai, China.
Wu, Qiang-Song; Wang, Xian; Liu, Jing-Yi; Chen, Yuan-Fang; Zhou, Qi; Wang, Yan; Sha, Ji-da; Xuan, Ze-Liang; Zhang, Lin-Wei; Yan, Lu; Hu, Yi.
Afiliación
  • Wu QS; Xuhui District Center for Disease Control and Prevention, Shanghai 200237, China.
  • Wang X; Xuhui District Center for Disease Control and Prevention, Shanghai 200237, China.
  • Liu JY; Xuhui District Center for Disease Control and Prevention, Shanghai 200237, China.
  • Chen YF; Xuhui District Center for Disease Control and Prevention, Shanghai 200237, China.
  • Zhou Q; Xuhui District Center for Disease Control and Prevention, Shanghai 200237, China.
  • Wang Y; Xuhui District Center for Disease Control and Prevention, Shanghai 200237, China.
  • Sha JD; Xuhui District Center for Disease Control and Prevention, Shanghai 200237, China.
  • Xuan ZL; Xuhui District Center for Disease Control and Prevention, Shanghai 200237, China.
  • Zhang LW; School of Public Health, University of South China, Hengyang 421001, China.
  • Yan L; Department of Epidemiology, China, and Key Laboratory of Public Health Safety (Fudan University), School of Public Health, Fudan University, Ministry of Education, Shanghai 200032, China.
  • Hu Y; Department of Epidemiology, China, and Key Laboratory of Public Health Safety (Fudan University), School of Public Health, Fudan University, Ministry of Education, Shanghai 200032, China. Electronic address: yhu@fudan.edu.cn.
Int J Infect Dis ; 89: 72-78, 2019 Dec.
Article en En | MEDLINE | ID: mdl-31521857
OBJECTIVE: To investigate varicella outbreak trends among schoolchildren during the voluntary single-dose varicella vaccine (VarV) era in Shanghai, China. METHODS: Trends in school varicella outbreaks from 2006 to 2017 were assessed using joinpoint regression models. The impacts of changes in single-dose VarV coverage among schoolchildren and implementation of post-exposure prophylaxis (PEP) strategies on outbreak trends were further analyzed. RESULTS: In total, 265 varicella outbreaks involving 3263 cases were reported in Shanghai from 2006 to 2017. The number of outbreaks showed an increasing trend from 2006 to 2017 (t=2.62, p=0.026), especially in kindergartens. The proportion of breakthrough varicella cases among all outbreak-related cases showed an increasing trend from 30.4% in 2008 to 85.7% in 2017 (t=7.45, p<0.001). Single-dose VarV coverage among schoolchildren was 88.1%, and showed a significant increase from the 1996 to the 2008 birth cohorts, followed by a non-significant decline from the 2008 to the 2014 birth cohorts. During school outbreaks in which PEP campaigns were conducted, the varicella attack rate was significantly lower than those in outbreaks without PEP campaigns (1.2% vs. 1.4%; Chi-square=23.35, p<0.001). CONCLUSIONS: Even with high coverage, single-dose VarV is insufficient to prevent school outbreaks. The administration of VarV as PEP is an appropriate intervention for varicella outbreak control prior to implementing a two-dose VarV schedule.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Varicela / Herpesvirus Humano 3 / Vacuna contra la Varicela Tipo de estudio: Incidence_studies / Prognostic_studies Límite: Adolescent / Child / Child, preschool / Female / Humans / Male País/Región como asunto: Asia Idioma: En Revista: Int J Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2019 Tipo del documento: Article País de afiliación: China Pais de publicación: Canadá
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Varicela / Herpesvirus Humano 3 / Vacuna contra la Varicela Tipo de estudio: Incidence_studies / Prognostic_studies Límite: Adolescent / Child / Child, preschool / Female / Humans / Male País/Región como asunto: Asia Idioma: En Revista: Int J Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2019 Tipo del documento: Article País de afiliación: China Pais de publicación: Canadá