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Draft genome sequence analysis of a high carbapenem-resistant Klebsiella quasipneumoniae subsp. quasipneumoniae strain isolated from an HIV-positive patient with pneumonia.
Gao, Jian-Yuan; Guo, Hui-Ming; Bao, Yu-Xia; Wang, Hua-Wei; Xie, Zhen-Rong; Chen, Feng-Rong; Ren, Li; Xu, Yu; Zhou, Shi-Yi; Yang, Bin; Wang, Kun-Hua.
Afiliación
  • Gao JY; Department of Vascular Surgery, the First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan, PR China; Yunnan Engineering Technology Center of Diagnosis and Treatment of Digestive Diseases, the First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan, P
  • Guo HM; Yunnan Engineering Technology Center of Diagnosis and Treatment of Digestive Diseases, the First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan, PR China; Yunnan Institute of Digestive Diseases, the First Affiliated Hospital of Kunming Medical University, Kunming 650032, Y
  • Bao YX; Department of Clinical Laboratory, the First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan, PR China; Yunnan Institute of Experimental Diagnosis, Kunming 650032, Yunnan, PR China; Yunnan Key Laboratory of Laboratory Medicine, Kunming 650032, Yunnan, PR China.
  • Wang HW; Yunnan Engineering Technology Center of Diagnosis and Treatment of Digestive Diseases, the First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan, PR China; Yunnan Institute of Digestive Diseases, the First Affiliated Hospital of Kunming Medical University, Kunming 650032, Y
  • Xie ZR; Yunnan Engineering Technology Center of Diagnosis and Treatment of Digestive Diseases, the First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan, PR China; Yunnan Institute of Digestive Diseases, the First Affiliated Hospital of Kunming Medical University, Kunming 650032, Y
  • Chen FR; Yunnan Engineering Technology Center of Diagnosis and Treatment of Digestive Diseases, the First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan, PR China; Yunnan Institute of Digestive Diseases, the First Affiliated Hospital of Kunming Medical University, Kunming 650032, Y
  • Ren L; Yunnan Engineering Technology Center of Diagnosis and Treatment of Digestive Diseases, the First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan, PR China; Yunnan Institute of Digestive Diseases, the First Affiliated Hospital of Kunming Medical University, Kunming 650032, Y
  • Xu Y; Yunnan Engineering Technology Center of Diagnosis and Treatment of Digestive Diseases, the First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan, PR China; Yunnan Institute of Digestive Diseases, the First Affiliated Hospital of Kunming Medical University, Kunming 650032, Y
  • Zhou SY; Yunnan Engineering Technology Center of Diagnosis and Treatment of Digestive Diseases, the First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan, PR China; Yunnan Institute of Digestive Diseases, the First Affiliated Hospital of Kunming Medical University, Kunming 650032, Y
  • Yang B; Department of Vascular Surgery, the First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan, PR China.
  • Wang KH; Yunnan Engineering Technology Center of Diagnosis and Treatment of Digestive Diseases, the First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan, PR China; Yunnan Institute of Digestive Diseases, the First Affiliated Hospital of Kunming Medical University, Kunming 650032, Y
J Glob Antimicrob Resist ; 19: 192-193, 2019 12.
Article en En | MEDLINE | ID: mdl-31520808
OBJECTIVES: The rapid spread of Klebsiella spp. is recognised as a major threat to public health owing to a rise in the number both of healthcare- and community-acquired infections. Here we report the draft genome sequence of a high carbapenem-resistant Klebsiella quasipneumoniae subsp. quasipneumoniae strain (Cln185) isolated from a human immunodeficiency virus (HIV)-positive patient with pneumonia. METHODS: Classical microbiological methods were applied to isolate and identify the strain. Genomic DNA was sequenced using an Illumina HiSeq platform and the reads were de novo assembled into contigs using CLC Genomics Workbench. The assembled contigs was annotated and whole-genome sequencing (WGS) was performed. RESULTS: WGS analysis revealed that the genome comprised a circular chromosome of 5 406 774bp with a GC content of 57.73%. Three important antimicrobial resistance genes (blaIMP-38, blaOKP-B-6 and blaDHA-1) were detected. In addition, genes conferring resistance to aminoglycosides, ß-lactams, fluoroquinolones and tetracycline were also identified. CONCLUSION: The draft genome sequence reported here will lay the foundation for future research on antimicrobial resistance and pathogenic mechanisms in K. quasipneumoniae subsp. quasipneumoniae and also will promote comparative analysis with genomic features among different sources of clinically important multidrug-resistant strains.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neumonía / Carbapenémicos / Infecciones por VIH / Farmacorresistencia Bacteriana Múltiple / Secuenciación Completa del Genoma / Klebsiella Límite: Adult / Humans / Male Idioma: En Revista: J Glob Antimicrob Resist Año: 2019 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neumonía / Carbapenémicos / Infecciones por VIH / Farmacorresistencia Bacteriana Múltiple / Secuenciación Completa del Genoma / Klebsiella Límite: Adult / Humans / Male Idioma: En Revista: J Glob Antimicrob Resist Año: 2019 Tipo del documento: Article Pais de publicación: Países Bajos