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Gastroesophageal reflux disease and atrial fibrillation: Insight from autonomic cardiogastric neural interaction.
Huang, Ting-Chun; Lo, Li-Wei; Yamada, Shinya; Chou, Yu-Hui; Lin, Wei-Lun; Chang, Shih-Lin; Lin, Yenn-Jiang; Liu, Shin-Huei; Cheng, Wen-Han; Tsai, Tsung-Ying; Liu, Ping-Yen; Chen, Shih-Ann.
Afiliación
  • Huang TC; Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
  • Lo LW; Division of Cardiology, Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
  • Yamada S; Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
  • Chou YH; Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
  • Lin WL; Institute of Clinical Medicine and Cardiovascular Research, National Yang-Ming University, Taipei, Taiwan.
  • Chang SL; Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
  • Lin YJ; Department of Cardiovascular Medicine, Fukushima Medical University, Fukushima, Japan.
  • Liu SH; Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
  • Cheng WH; Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
  • Tsai TY; Institute of Clinical Medicine and Cardiovascular Research, National Yang-Ming University, Taipei, Taiwan.
  • Liu PY; Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
  • Chen SA; Institute of Clinical Medicine and Cardiovascular Research, National Yang-Ming University, Taipei, Taiwan.
J Cardiovasc Electrophysiol ; 30(11): 2262-2270, 2019 11.
Article en En | MEDLINE | ID: mdl-31515888
BACKGROUND: The relationship between gastroesophageal reflux disease (GERD) and atrial fibrillation (AF) has been previously reported. However, the detailed mechanism remains unknown. In this study, we investigated the effects of acid reflux on the intrinsic cardiac autonomic nervous system, atrial/ventricular electrophysiology, and AF inducibility. METHODS: Eighteen rabbits were randomized into three groups: acid reflux (group 1, n = 6), control (group 2, n = 6), and acid reflux with periesophageal vagal blockade (group 3, n = 6). Atrial and ventricular effective refractory periods (ERPs) and AF inducibility were checked at baseline and then hourly until 5 hours after the experiment. RESULTS: Three hours after the experiment, atrial ERP prolongation was noted in groups 2 and 3 (P < .05), whereas shortening of the atrial ERPs was observed in group 1, compared with the baseline. However, no changes were observed in ventricular ERPs in the three groups. The AF inducibility was higher in group 1 than in groups 2 and 3. Pathological examination showed clear esophageal mucosal breaks in groups 1 and 3. CONCLUSIONS: In this study, we found that the antimuscarinic blockade prevents GERD induced changes to atrial electrophysiology and susceptibility to AF-making it highly likely that autonomic activity is important in mediating this effect.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fibrilación Atrial / Sistema Nervioso Autónomo / Potenciales de Acción / Reflujo Gastroesofágico / Esófago / Corazón / Frecuencia Cardíaca Tipo de estudio: Diagnostic_studies / Etiology_studies / Prognostic_studies Límite: Animals Idioma: En Revista: J Cardiovasc Electrophysiol Asunto de la revista: ANGIOLOGIA / CARDIOLOGIA / FISIOLOGIA Año: 2019 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fibrilación Atrial / Sistema Nervioso Autónomo / Potenciales de Acción / Reflujo Gastroesofágico / Esófago / Corazón / Frecuencia Cardíaca Tipo de estudio: Diagnostic_studies / Etiology_studies / Prognostic_studies Límite: Animals Idioma: En Revista: J Cardiovasc Electrophysiol Asunto de la revista: ANGIOLOGIA / CARDIOLOGIA / FISIOLOGIA Año: 2019 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Estados Unidos