[Metamizol-caffeine elimination in females with increased serum aminotransferase activities treated with steroidal oral contraceptives]. / Die Metamizol-Coffein-Elimination bei Frauen mit erhöhten Aminotransferase-Aktivitäten im Serum unter steroidalen oralen Kontrazeptiva.
Dtsch Z Verdau Stoffwechselkr
; 48(5): 261-7, 1988.
Article
en De
| MEDLINE
| ID: mdl-3150832
ABSTRACT
PIP: The elimination of caffeine from the plasma and the excretion of the major metabolites of metamizol (Analgin) in the urine was studied in 25 women on longterm oral contraceptives (OCs). Both tests allowed for conclusions about metabolic liver function. A steroid-induced delay of the elimination of caffeine in clinically healthy women with and without serologic elevation of aminotransferase activities was demonstrated. The author's regard this as the consequence of an inhibition of the cytochrome p-450-dependent polyfunctioned oxidases of the P-450 MC type, which was produced by OCs. The differences in the elimination of metamizol were not significant. (author's)
Palabras clave
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Aspartato Aminotransferasas
/
Cafeína
/
Aminopirina
/
Dipirona
/
Anticonceptivos Hormonales Orales
/
Alanina Transaminasa
/
Pruebas de Función Hepática
Límite:
Adult
/
Female
/
Humans
Idioma:
De
Revista:
Dtsch Z Verdau Stoffwechselkr
Año:
1988
Tipo del documento:
Article
Pais de publicación:
Alemania