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Parental disclosure of positive BRCA1/2 mutation status to children 10 years after genetic testing.
Troïan, Jaïs; Apostolidis, Thémis; Touzani, Rajae; Mouret-Fourme, Emmanuelle; Stoppa-Lyonnet, Dominique; Lasset, Christine; Berthet, Pascaline; Julian-Reynier, Claire; Mancini, Julien; Noguès, Catherine; Bouhnik, Anne-Déborah.
Afiliación
  • Troïan J; Aix-Marseille Université, LPS EA 849 , Aix en Provence, France.
  • Apostolidis T; Aix Marseille Univ, INSERM, IRD, SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l'Information Médicale , Marseille, France.
  • Touzani R; Aix-Marseille Université, LPS EA 849 , Aix en Provence, France.
  • Mouret-Fourme E; Aix Marseille Univ, INSERM, IRD, SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l'Information Médicale , Marseille, France.
  • Stoppa-Lyonnet D; Department of Genetics, Institut Curie , Paris, France.
  • Lasset C; Department of Genetics, Institut Curie , Paris, France.
  • Berthet P; Institut Curie, INSERM U830 , Paris, France.
  • Julian-Reynier C; Université Paris Descartes, Sorbonne Paris Cité.
  • Mancini J; Département de Santé Publique, Centre Léon Bérard , Lyon, France.
  • Noguès C; CNRS UMR 5558, Laboratoire de Biométrie et Biologie Evolutive Lyon , France.
  • Bouhnik AD; Université de Lyon , Lyon, France.
Psychol Health Med ; 25(6): 756-766, 2020 07.
Article en En | MEDLINE | ID: mdl-31505944
The disclosure of genetic information is an important issue in cancer prevention. This study based on a French national cohort of BRCA1/2 mutation carriers (GENEPSO-PS cohort, N=233) aimed to assess the prevalence of parental disclosure of genetic information to children 10 years after genetic testing, with a focus on gender differences. Most participants (n = 193, 131 women) reported having children. A total of 72.0% of offspring had received genetic information (88.8% for adult offspring, p < .001), with no differences according to the gender of the mutation-carrying parent. While female carriers disclosed genetic information more often than male carriers (54.1% versus 38.3%, p = .029), they did so irrespective of the gender of their offspring. Moreover, female carriers who had developed incident cancer after genetic testing disclosed genetic information more frequently than unaffected female carriers (70.7% versus 48.5%, p = .005). A multivariate analysis confirmed the effects of both gender and cancer on disclosure to offspring. The same results were obtained when the analysis was restricted to adult offspring. This study reveals high rates of disclosure of positive BRCA1/2 mutation status to children 10 years after genetic testing, irrespective of the gender of the carrier/offspring. However, female carriers disclosed genetic information more frequently than male carriers.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Padres / Revelación / Síndrome de Cáncer de Mama y Ovario Hereditario / Mutación Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Aged / Child / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Psychol Health Med Asunto de la revista: MEDICINA / SERVICOS DE SAUDE Año: 2020 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Padres / Revelación / Síndrome de Cáncer de Mama y Ovario Hereditario / Mutación Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Aged / Child / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Psychol Health Med Asunto de la revista: MEDICINA / SERVICOS DE SAUDE Año: 2020 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Reino Unido