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Surgical Outcomes and Risk Analysis of Primary Pulmonary Sarcoma.
Yamada, Yoshito; Kaplan, Tevfik; Soltermann, Alex; Schmitt-Opitz, Isabelle; Schneiter, Didier; Weder, Walter; Inci, Ilhan.
Afiliación
  • Yamada Y; Department of Thoracic Surgery, University Hospital Zurich, Zurich, Switzerland.
  • Kaplan T; Department of Thoracic Surgery, Kyoto University Hospital, Kyoto, Japan.
  • Soltermann A; Department of Thoracic Surgery, Ufuk University School of Medicine, Ankara, Çankaya, Turkey.
  • Schmitt-Opitz I; Institute of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland.
  • Schneiter D; Department of Thoracic Surgery, University Hospital Zurich, Zurich, Switzerland.
  • Weder W; Department of Thoracic Surgery, University Hospital Zurich, Zurich, Switzerland.
  • Inci I; Department of Thoracic Surgery, University Hospital Zurich, Zurich, Switzerland.
Thorac Cardiovasc Surg ; 69(1): 101-108, 2021 01.
Article en En | MEDLINE | ID: mdl-31499540
BACKGROUND: Primary pulmonary sarcoma (PPS) is a rare malignant lung neoplasm, and there is very little medical evidence about treatment of PPS. The aim of this study is to clarify the clinical characteristics and therapeutic outcome of patients who underwent surgical resection for PPS. METHODS: We retrospectively reviewed the records of patients who underwent surgical resection for PPS in our institution between 1995 and 2014. Cases who only underwent biopsy were excluded. RESULTS: A total of 24 patients (18 males, 6 females), with a median age of 60 (interquartile range: 44-67) years, were analyzed. The surgical procedures performed in these patients were pneumonectomy (n = 10), lobectomy (n = 11), and wedge resection (n = 3). Complete resection was achieved in 16 patients. The pathological stages (tumor, node, metastases lung cancer classification, 8th edition) of the patients were I (n = 4), II (n = 12), III (n = 2), and IV (n = 5), and there were four cases of lymph node metastasis. The 5-year overall survival rate of the patients was 50% (95% confidence interval [CI]: 29-72). Adverse prognostic factors for overall survival were incomplete resection (hazard ratio [HR]: 4.4, 95% CI: 2.1-42), advanced pathological stage (HR 14, 95% CI: 2.8-66), higher pathological grade (HR 4.5, 95% CI: 1.2-17), and tumor size ≥ 7 cm (HR 4.7, 95% CI: 1.1-21). CONCLUSIONS: Our series of PPS revealed that incomplete resection, advanced pathological stage, higher pathological grade, and tumor size were unfavorable factors for long-term survival.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neumonectomía / Sarcoma / Neoplasias Pulmonares Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Thorac Cardiovasc Surg Año: 2021 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Alemania
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neumonectomía / Sarcoma / Neoplasias Pulmonares Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Thorac Cardiovasc Surg Año: 2021 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Alemania