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Serum lipids and risk of atherosclerosis in xanthelasma palpebrarum: A systematic review and meta-analysis.
Chang, Hua-Ching; Sung, Chih-Wei; Lin, Ming-Hsiu.
Afiliación
  • Chang HC; Department of Dermatology, Taipei Medical University Hospital, Taipei, Taiwan.
  • Sung CW; Department of Emergency Medicine, National Taiwan University Hospital Hsin-Chu Branch, Hsinchu, Taiwan.
  • Lin MH; Department of Dermatology, Taipei Medical University Hospital, Taipei, Taiwan; Department of Dermatology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan. Electronic address: living-white@yahoo.com.tw.
J Am Acad Dermatol ; 82(3): 596-605, 2020 Mar.
Article en En | MEDLINE | ID: mdl-31499151
BACKGROUND: The association between dyslipidemia and xanthelasma palpebrarum (XP) remains controversial, and no definite evidence has indicated atherosclerosis risk in patients with XP. OBJECTIVE: The present study was a systematic review and meta-analysis to elucidate the association of serum lipid profiles and risk of atherosclerotic diseases with XP. METHODS: We systematically searched for the eligible comparative studies published before April 15, 2019, in the databases of PubMed, Web of Science, Embase, and Cochrane Library. A random-effects model was used to calculate the standard mean difference with 95% confidence interval for each pooled estimate. RESULTS: The qualitative analyses included 15 case-control studies with 854 patients with XP. Compared with the controls, the patients with XP had significantly higher serum levels of total cholesterol and low-density lipoproteins, significantly higher apolipoprotein B levels, and relatively lower apolipoprotein A1 levels, and the carotid intima-media thickness was significantly higher. CONCLUSION: Patients with XP had significantly higher serum levels of atherogenic low-density lipoproteins and bore significantly higher risk of atherosclerosis than the controls. Careful monitoring and targeted intervention for prevention of cardiovascular diseases is essential for these patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Xantomatosis / Aterosclerosis / Párpados / Lipoproteínas LDL Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Qualitative_research / Risk_factors_studies / Systematic_reviews Límite: Humans Idioma: En Revista: J Am Acad Dermatol Año: 2020 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Xantomatosis / Aterosclerosis / Párpados / Lipoproteínas LDL Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Qualitative_research / Risk_factors_studies / Systematic_reviews Límite: Humans Idioma: En Revista: J Am Acad Dermatol Año: 2020 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Estados Unidos