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Contrast Enhanced Digital Mammography (CEDM) Helps to Safely Reduce Benign Breast Biopsies for Low to Moderately Suspicious Soft Tissue Lesions.
Zuley, Margarita L; Bandos, Andriy I; Abrams, Gordon S; Ganott, Marie A; Gizienski, Terri-Ann; Hakim, Christiane M; Kelly, Amy E; Nair, Bronwyn E; Sumkin, Jules H; Waheed, Uzma; Gur, David.
Afiliación
  • Zuley ML; University of Pittsburgh, School of Medicine & University of Pittsburgh Medical Center, Magee-Womens Hospital, Department of Radiology, Division of Breast Imaging, 300 Halket Street, Pittsburgh PA 15213, USA. Electronic address: zuleyml@upmc.edu.
  • Bandos AI; University of Pittsburgh, Graduate School of Public Health, Biostatistics, Pittsburgh Pennsylvania.
  • Abrams GS; University of Pittsburgh, School of Medicine & University of Pittsburgh Medical Center, Magee-Womens Hospital, Department of Radiology, Division of Breast Imaging, 300 Halket Street, Pittsburgh PA 15213, USA.
  • Ganott MA; University of Pittsburgh, School of Medicine & University of Pittsburgh Medical Center, Magee-Womens Hospital, Department of Radiology, Division of Breast Imaging, 300 Halket Street, Pittsburgh PA 15213, USA.
  • Gizienski TA; University of Pittsburgh, School of Medicine & University of Pittsburgh Medical Center, Magee-Womens Hospital, Department of Radiology, Division of Breast Imaging, 300 Halket Street, Pittsburgh PA 15213, USA.
  • Hakim CM; University of Pittsburgh, School of Medicine & University of Pittsburgh Medical Center, Magee-Womens Hospital, Department of Radiology, Division of Breast Imaging, 300 Halket Street, Pittsburgh PA 15213, USA.
  • Kelly AE; University of Pittsburgh, School of Medicine & University of Pittsburgh Medical Center, Magee-Womens Hospital, Department of Radiology, Division of Breast Imaging, 300 Halket Street, Pittsburgh PA 15213, USA.
  • Nair BE; University of Pittsburgh, School of Medicine & University of Pittsburgh Medical Center, Magee-Womens Hospital, Department of Radiology, Division of Breast Imaging, 300 Halket Street, Pittsburgh PA 15213, USA.
  • Sumkin JH; University of Pittsburgh, School of Medicine & University of Pittsburgh Medical Center, Magee-Womens Hospital, Department of Radiology, Division of Breast Imaging, 300 Halket Street, Pittsburgh PA 15213, USA.
  • Waheed U; University of Pittsburgh, School of Medicine & University of Pittsburgh Medical Center, Magee-Womens Hospital, Department of Radiology, Division of Breast Imaging, 300 Halket Street, Pittsburgh PA 15213, USA.
  • Gur D; University of Pittsburgh, School of Medicine, Department of Radiology, Imaging Research, Pittsburgh Pennsylvania.
Acad Radiol ; 27(7): 969-976, 2020 07.
Article en En | MEDLINE | ID: mdl-31495761
RATIONALE AND OBJECTIVES: To preliminarily asses if Contrast Enhanced Digital Mammography (CEDM) can accurately reduce biopsy rates for soft tissue BI-RADS 4A or 4B lesions. MATERIALS AND METHODS: Eight radiologists retrospectively and independently reviewed 60 lesions in 54 consenting patients who underwent CEDM under Health Insurance Portability and Accountability Act compliant institutional review board-approved protocols. Readers provided Breast Imaging Reporting & Data System ratings sequentially for digital mammography/digital breast tomosynthesis (DM/DBT), then with ultrasound, then with CEDM for each lesion. Area under the curve (AUC), true positive rates and false positive rates, positive predictive values and negative predictive values were calculated. Statistical analysis accounting for correlation between lesion-examinations and between-reader variability was performed using OR/DBM (for SAS v.3.0), generalized linear mixed model for binary data (proc glimmix, SAS v.9.4, SAS Institute, Cary North Carolina), and bootstrap. RESULTS: The cohort included 49 benign, two high-risk and nine cancerous lesions in 54 women aged 34-74 (average 50) years. Reader-averaged AUC for CEDM was significantly higher than DM/DBT alone (0.85 versus 0.66, p < 0.001) or with US (0.85 versus 0.75, p = 0.001). CEDM increased true positive rates from 0.74 under DB/DBT, and 0.89 with US, to 0.90 with CEDM, (p = 0.019 DM/DBT versus CEDM, p = 0.78 DM/DBT + US versus CEDM) and decreased false positive rates from 0.47 using DM/DBT and 0.61 with US to 0.39 with CEDM (p = 0.017 DM/DBT versus CEDM, p = 0.001 DM/DBT+ US versus CEDM). For an expected cancer rate of 10%, CEDM positive predictive values was 20.5% (95% CI: 16%-27%) and negative predictive values 98.3% (95% CI: 96%-100%). CONCLUSION: Addition of CEDM for evaluation of low-moderate suspicion soft tissue breast lesions can substantially reduce biopsy of benign lesions without compromising cancer detection.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Middle aged País/Región como asunto: America do norte Idioma: En Revista: Acad Radiol Asunto de la revista: RADIOLOGIA Año: 2020 Tipo del documento: Article Pais de publicación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Middle aged País/Región como asunto: America do norte Idioma: En Revista: Acad Radiol Asunto de la revista: RADIOLOGIA Año: 2020 Tipo del documento: Article Pais de publicación: Estados Unidos