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From multi-target anticoagulants to DOACs, and intrinsic coagulation factor inhibitors.
Lin, Lisha; Zhao, Longyan; Gao, Na; Yin, Ronghua; Li, Sujuan; Sun, Huifang; Zhou, Lutan; Zhao, Guiling; Purcell, Steven W; Zhao, Jinhua.
Afiliación
  • Lin L; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China; University of Chinese Academy of Sciences, College of Life Sciences, Beijing 100049, China. Electronic address: liesellin@yahoo.com.
  • Zhao L; School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, China. Electronic address: zhaolongyan@mail.scuec.edu.cn.
  • Gao N; School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, China. Electronic address: gn2008.happy@163.com.
  • Yin R; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China. Electronic address: yinronghua@mail.kib.ac.cn.
  • Li S; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China; University of Chinese Academy of Sciences, College of Life Sciences, Beijing 100049, China. Electronic address: lisujuan@mail.kib.ac.cn.
  • Sun H; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China; University of Chinese Academy of Sciences, College of Life Sciences, Beijing 100049, China. Electronic address: sunhuifang@mail.kib.ac.cn.
  • Zhou L; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China; University of Chinese Academy of Sciences, College of Life Sciences, Beijing 100049, China. Electronic address: zhoulutan@mai.kib.ac.cn.
  • Zhao G; Department of Physiology & Center for Biomedical Engineer and Technology, University of Maryland School of Medicine, Baltimore, MD 21201, United States of America. Electronic address: GZhao@som.umaryland.edu.
  • Purcell SW; National Marine Science Centre, Southern Cross University, Charlesworth Bay, Coffs Harbour, NSW 2450, Australia. Electronic address: Steven.Purcell@scu.edu.au.
  • Zhao J; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China. Electronic address: zhao.jinhua@yahoo.com.
Blood Rev ; 39: 100615, 2020 01.
Article en En | MEDLINE | ID: mdl-31492462
From the 1940s to 1990s, heparin and warfarin have been the main anticoagulants for the prevention and treatment of thrombotic events. Since then, LMWHs and fondaparinux proved effective in clinical trials, with better pharmacokinetic profiles and no monitoring requirements. Developed in the early 21st century, DOACs have comparable efficacy to LMWHs, but increase bleeding risk, as the anticoagulant targets (FIIa, FXa) are also essential for physiological hemostasis. In contrast, selective inhibition of the intrinsic coagulation pathway may be a promising strategy for safer antithrombotic treatment. FXII, FXI and FIX inhibitors have produced favorable results in preclinical studies. Notably, intrinsic F.Xase is another promising candidate target, yet to be systematically evaluated. Here, we review the development of anticoagulants, including recent research on intrinsic F.Xase inhibitors, and the revision of coagulation models over time. Studies support optimism for future diversification of anticoagulants, which could offer more reliable and patient-specific therapy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Factores de Coagulación Sanguínea / Heparina de Bajo-Peso-Molecular / Anticoagulantes Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Blood Rev Asunto de la revista: HEMATOLOGIA Año: 2020 Tipo del documento: Article Pais de publicación: Reino Unido
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Factores de Coagulación Sanguínea / Heparina de Bajo-Peso-Molecular / Anticoagulantes Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Blood Rev Asunto de la revista: HEMATOLOGIA Año: 2020 Tipo del documento: Article Pais de publicación: Reino Unido