Novel Molecular Hybrids of <i>N</i>-Benzylpiperidine and 1,3,4-Oxadiazole as Multitargeted Therapeutics to Treat Alzheimer's Disease.

Sharma, Piyoosh; Tripathi, Avanish; Tripathi, Prabhash Nath; Singh, Saumitra Sen; Singh, Surya Pratap; Shrivastava, Sushant Kumar

Novel Molecular Hybrids of N-Benzylpiperidine and 1,3,4-Oxadiazole as Multitargeted Therapeutics to Treat Alzheimer's Disease.

Sharma, Piyoosh; Tripathi, Avanish; Tripathi, Prabhash Nath; Singh, Saumitra Sen; Singh, Surya Pratap; Shrivastava, Sushant Kumar.

Afiliación

Sharma P; Department of Pharmaceutical Engineering & Technology , Indian Institute of Technology (Banaras Hindu University) , Varanasi 221 005 , India.
Tripathi A; Department of Pharmaceutical Engineering & Technology , Indian Institute of Technology (Banaras Hindu University) , Varanasi 221 005 , India.
Tripathi PN; Department of Pharmaceutical Engineering & Technology , Indian Institute of Technology (Banaras Hindu University) , Varanasi 221 005 , India.
Singh SS; Department of Biochemistry, Faculty of Science , Banaras Hindu University , Varanasi 221 005 , India.
Singh SP; Department of Biochemistry, Faculty of Science , Banaras Hindu University , Varanasi 221 005 , India.
Shrivastava SK; Department of Pharmaceutical Engineering & Technology , Indian Institute of Technology (Banaras Hindu University) , Varanasi 221 005 , India.

ACS Chem Neurosci ; 10(10): 4361-4384, 2019 10 16.

Article en En | MEDLINE | ID: mdl-31491074

Asunto(s)

Enfermedad de Alzheimer/tratamiento farmacológico; Encéfalo/efectos de los fármacos; Oxadiazoles/uso terapéutico; Piperidinas/uso terapéutico; Acetilcolinesterasa/metabolismo; Enfermedad de Alzheimer/metabolismo; Secretasas de la Proteína Precursora del Amiloide/metabolismo; Péptidos beta-Amiloides/metabolismo; Animales; Ácido Aspártico Endopeptidasas/metabolismo; Encéfalo/metabolismo; Diseño de Fármacos; Simulación del Acoplamiento Molecular; Oxadiazoles/farmacología; Piperidinas/farmacología; Ratas; Relación Estructura-Actividad

Palabras clave

Alzheimer's disease; Multitargeted hybrids; acetylcholinesterase (AChE); butyrylcholinesterase (BChE); ß-secretase-1 (BACE-1)

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oxadiazoles / Piperidinas / Encéfalo / Enfermedad de Alzheimer Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: ACS Chem Neurosci Año: 2019 Tipo del documento: Article País de afiliación: India Pais de publicación: Estados Unidos

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