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Hair follicle regeneration suppresses Ras-driven oncogenic growth.
Pineda, Cristiana M; Gonzalez, David G; Matte-Martone, Catherine; Boucher, Jonathan; Lathrop, Elizabeth; Gallini, Sara; Fons, Nathan R; Xin, Tianchi; Tai, Karen; Marsh, Edward; Nguyen, Don X; Suozzi, Kathleen C; Beronja, Slobodan; Greco, Valentina.
Afiliación
  • Pineda CM; Department of Genetics, Yale School of Medicine, New Haven, CT.
  • Gonzalez DG; Department of Genetics, Yale School of Medicine, New Haven, CT.
  • Matte-Martone C; Department of Genetics, Yale School of Medicine, New Haven, CT.
  • Boucher J; Department of Genetics, Yale School of Medicine, New Haven, CT.
  • Lathrop E; Department of Genetics, Yale School of Medicine, New Haven, CT.
  • Gallini S; Department of Genetics, Yale School of Medicine, New Haven, CT.
  • Fons NR; Department of Therapeutic Radiology, Yale School of Medicine, New Haven, CT.
  • Xin T; Department of Genetics, Yale School of Medicine, New Haven, CT.
  • Tai K; Department of Genetics, Yale School of Medicine, New Haven, CT.
  • Marsh E; Department of Genetics, Yale School of Medicine, New Haven, CT.
  • Nguyen DX; Depatment of Pathology, Yale School of Medicine, New Haven, CT.
  • Suozzi KC; Department of Genetics, Yale School of Medicine, New Haven, CT.
  • Beronja S; Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA.
  • Greco V; Department of Genetics, Yale School of Medicine, New Haven, CT valentina.greco@yale.edu.
J Cell Biol ; 218(10): 3212-3222, 2019 10 07.
Article en En | MEDLINE | ID: mdl-31488583
Mutations associated with tumor development in certain tissues can be nontumorigenic in others, yet the mechanisms underlying these different outcomes remains poorly understood. To address this, we targeted an activating Hras mutation to hair follicle stem cells and discovered that Hras mutant cells outcompete wild-type neighbors yet are integrated into clinically normal skin hair follicles. In contrast, targeting the Hras mutation to the upper noncycling region of the skin epithelium leads to benign outgrowths. Follicular Hras mutant cells autonomously and nonautonomously enhance regeneration, which directs mutant cells into continuous tissue cycling to promote integration rather than aberrancy. This follicular tolerance is maintained under additional challenges that promote tumorigenesis in the epidermis, including aging, injury, and a secondary mutation. Thus, the hair follicle possesses a unique, enhanced capacity to integrate and contain Hras mutant cells within both homeostatic and perturbed tissue, demonstrating that in the skin, multiple, distinct mechanisms exist to suppress oncogenic growth.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Regeneración / Proteínas ras / Folículo Piloso / Carcinogénesis / Neoplasias Límite: Animals Idioma: En Revista: J Cell Biol Año: 2019 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Regeneración / Proteínas ras / Folículo Piloso / Carcinogénesis / Neoplasias Límite: Animals Idioma: En Revista: J Cell Biol Año: 2019 Tipo del documento: Article Pais de publicación: Estados Unidos