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Effect of Weight Change Following Intentional Weight Loss on Bone Health in Older Adults with Obesity.
Kammire, Daniel E; Walkup, Michael P; Ambrosius, Walter T; Lenchik, Leon; Shapses, Sue A; Nicklas, Barbara J; Houston, Denise K; Marsh, Anthony P; Rejeski, W Jack; Beavers, Kristen M.
Afiliación
  • Kammire DE; Department of Health and Exercise Science, Wake Forest University, Winston-Salem, North Carolina, USA.
  • Walkup MP; Department of Biostatistics and Data Science, School of Medicine, Wake Forest University, Winston-Salem, North Carolina, USA.
  • Ambrosius WT; Department of Biostatistics and Data Science, School of Medicine, Wake Forest University, Winston-Salem, North Carolina, USA.
  • Lenchik L; Department of Radiology, School of Medicine, Wake Forest University, Winston-Salem, North Carolina, USA.
  • Shapses SA; Department of Nutritional Sciences, Rutgers University, New Brunswick, New Jersey, USA.
  • Nicklas BJ; Department of Internal Medicine, School of Medicine, Wake Forest University, Winston-Salem, North Carolina, USA.
  • Houston DK; Department of Internal Medicine, School of Medicine, Wake Forest University, Winston-Salem, North Carolina, USA.
  • Marsh AP; Department of Health and Exercise Science, Wake Forest University, Winston-Salem, North Carolina, USA.
  • Rejeski WJ; Department of Health and Exercise Science, Wake Forest University, Winston-Salem, North Carolina, USA.
  • Beavers KM; Department of Health and Exercise Science, Wake Forest University, Winston-Salem, North Carolina, USA.
Obesity (Silver Spring) ; 27(11): 1839-1845, 2019 11.
Article en En | MEDLINE | ID: mdl-31486297
OBJECTIVE: This study aimed to examine change in bone mineral density (BMD) and trabecular bone score among older adult weight regainers (WR) and weight maintainers (WM). METHODS: Observational data come from 77 older adults (mean age: 67 [SD 5] years; 69% women; 70% white) with obesity (mean BMI: 33.6 [SD 3.7] kg/m2 ) who lost weight during an 18-month weight loss intervention. Total body mass and body composition, along with regional (total hip, femoral neck, lumbar spine) BMD and trabecular bone score, were measured at baseline, 18 months, and 30 months. WR (n = 36) and WM (n = 41) categories were defined as a ≥ 5% or < 5% weight gain from 18 to 30 months, respectively. RESULTS: Among skeletal indices, only total hip BMD was significantly reduced during the 18-month intervention period in both WRs (-3.9%; 95% CI: -5.8% to -2.0%) and WMs (-2.4%; 95% CI: -4.3% to -0.5%; P = 0.07). After adjustment for relevant baseline covariates and weight change from 0 to 18 months, 30-month change in total hip BMD was -2.6% (95% CI: -4.3% to -0.9%) and -3.9% (95% CI: -5.7% to -2.1%) among WRs and WMs, respectively (P = 0.07). CONCLUSIONS: Loss of hip BMD persists in the year after a weight loss intervention among older adults with obesity, regardless of weight regain status.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Envejecimiento / Pérdida de Peso / Densidad Ósea / Programas de Reducción de Peso / Obesidad Tipo de estudio: Clinical_trials / Observational_studies / Prognostic_studies / Risk_factors_studies Aspecto: Patient_preference Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Obesity (Silver Spring) Asunto de la revista: CIENCIAS DA NUTRICAO / FISIOLOGIA / METABOLISMO Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Envejecimiento / Pérdida de Peso / Densidad Ósea / Programas de Reducción de Peso / Obesidad Tipo de estudio: Clinical_trials / Observational_studies / Prognostic_studies / Risk_factors_studies Aspecto: Patient_preference Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Obesity (Silver Spring) Asunto de la revista: CIENCIAS DA NUTRICAO / FISIOLOGIA / METABOLISMO Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos