DUBbing Down Translation: The Functional Interaction of Deubiquitinases with the Translational Machinery.
Mol Cancer Ther
; 18(9): 1475-1483, 2019 09.
Article
en En
| MEDLINE
| ID: mdl-31481479
Cancer cells revamp the regulatory processes that control translation to induce tumor-specific translational programs that can adapt to a hostile microenvironment as well as withstand anticancer therapeutics. Translational initiation has been established as a common downstream effector of numerous deregulated signaling pathways that together culminate in prooncogenic expression. Other mechanisms, including ribosomal stalling and stress granule assembly, also appear to be rewired in the malignant phenotype. Therefore, better understanding of the underlying perturbations driving oncogenic translation in the transformed state will provide innovative therapeutic opportunities. This review highlights deubiquitinating enzymes that are activated/dysregulated in hematologic malignancies, thereby altering the translational output and contributing to tumorigenesis.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Biosíntesis de Proteínas
/
Proteínas Proto-Oncogénicas
/
Neoplasias Hematológicas
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Carcinogénesis
/
Enzimas Desubicuitinizantes
Límite:
Humans
Idioma:
En
Revista:
Mol Cancer Ther
Asunto de la revista:
ANTINEOPLASICOS
Año:
2019
Tipo del documento:
Article
Pais de publicación:
Estados Unidos