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Evaluation of potential biomarkers for the diagnosis and monitoring of Systemic Lupus Erythematosus using the Cytometric Beads Array (CBA).
Alves, L C V; Carvalho, M G; Nunes, F F C; Reis, E A; Ferreira, G A; Calderaro, D C; Carvalho, J S; Pádua, P M; Cicarini, W B; Gondim, I M; Ferreira, L F; Guimarães, T M P D; Toledo, V P C P.
Afiliación
  • Alves LCV; Department of Clinical and Toxicological Analysis, Faculty of Pharmacy, Federal University of Minas Gerais, Brazil.
  • Carvalho MG; Department of Clinical and Toxicological Analysis, Faculty of Pharmacy, Federal University of Minas Gerais, Brazil.
  • Nunes FFC; Department of Clinical and Toxicological Analysis, Faculty of Pharmacy, Federal University of Minas Gerais, Brazil.
  • Reis EA; Department of Statistics, Institute of Exact Sciences, Federal University of Minas Gerais, Brazil.
  • Ferreira GA; Department of Locomotor System, Federal University of Minas Gerais, Brazil.
  • Calderaro DC; Department of Locomotor System, Federal University of Minas Gerais, Brazil.
  • Carvalho JS; Department of Locomotor System, Federal University of Minas Gerais, Brazil.
  • Pádua PM; Santa Casa of Belo Horizonte, Minas Gerais, Brazil.
  • Cicarini WB; Department of Clinical and Toxicological Analysis, Faculty of Pharmacy, Federal University of Minas Gerais, Brazil.
  • Gondim IM; Department of Clinical and Toxicological Analysis, Faculty of Pharmacy, Federal University of Minas Gerais, Brazil.
  • Ferreira LF; Department of Clinical and Toxicological Analysis, Faculty of Pharmacy, Federal University of Minas Gerais, Brazil.
  • Guimarães TMPD; Department of Clinical and Toxicological Analysis, Faculty of Pharmacy, Federal University of Minas Gerais, Brazil.
  • Toledo VPCP; Department of Clinical and Toxicological Analysis, Faculty of Pharmacy, Federal University of Minas Gerais, Brazil. Electronic address: vtoledo@ufmg.br.
Clin Chim Acta ; 499: 16-23, 2019 Dec.
Article en En | MEDLINE | ID: mdl-31479651
BACKGROUND: Systemic Lupus Erythematosus (SLE) is an autoimmune, multisystemic disease. Currently diagnosis depends on complex criteria developed by the American College of Rheumatology. Moreover, the lack of specific biomarkers also challenges the diagnosis. METHODS: Inflammatory biomarkers such as IL-8, IP-10, MIG, MIP-1α and RANTES were measured in serum samples from SLE patients and subjects in control groups (patients with other autoimmune diseases and healthy individuals). Forty-six SLE patients (22 patients with low activity, SLEDAI-2 K ≤ 4, 24 patients with moderate/high activity, SLEDAI-2 K > 4), 42 patients with other autoimmune diseases (OAD group), and 8 healthy volunteers participated in this study. RESULTS: MIG (p < .001) and RANTES (p < .001) concentrations in SLE patients and healthy controls, and IP-10 concentrations in SLE patients with different disease activities (low activity, p < .01, moderate/high activity, p < .05) differed significantly. IL-8 (p < .001) and MIP-1α (p < .001) concentrations in SLE patients differed from those in patients from the OAD group. IL-8 (p < .05), IP-10 (p < .01), MIG (p < .05), MIP-1α (p < .001), and RANTES (p < .05) were correlated with SLE activity; their concentrations in SLE patients with low and moderate/high activity differed significantly. CONCLUSIONS: Given the findings of this study, one can envision the possibility of future use of some of these cytokines to assist in the screening of SLE patients, or even in monitoring disease activity.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Citocinas / Citometría de Flujo / Lupus Eritematoso Sistémico Tipo de estudio: Diagnostic_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Clin Chim Acta Año: 2019 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Citocinas / Citometría de Flujo / Lupus Eritematoso Sistémico Tipo de estudio: Diagnostic_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Clin Chim Acta Año: 2019 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Países Bajos