Your browser doesn't support javascript.
loading
Roux-en-Y gastric bypass surgery progressively alters radiologic measures of hypothalamic inflammation in obese patients.
Hankir, Mohammed K; Rullmann, Michael; Seyfried, Florian; Preusser, Sven; Poppitz, Sindy; Heba, Stefanie; Gousias, Konstantinos; Hoyer, Jana; Schütz, Tatjana; Dietrich, Arne; Müller, Karsten; Pleger, Burkhard.
Afiliación
  • Hankir MK; Department of Experimental Surgery, University Hospital Wuerzburg, Wuerzburg, Germany.
  • Rullmann M; IFB AdiposityDiseases and.
  • Seyfried F; Department of Nuclear Medicine, University Hospital Leipzig, Germany.
  • Preusser S; Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.
  • Poppitz S; Collaborative Research Centre 1052 in Obesity Mechanisms, University of Leipzig, Leipzig, Germany.
  • Heba S; Department of General, Visceral, Vascular and Pediatric Surgery, University Hospital Wuerzburg, Wuerzburg, Germany.
  • Gousias K; Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.
  • Hoyer J; IFB AdiposityDiseases and.
  • Schütz T; Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.
  • Dietrich A; Department of Neurology and.
  • Müller K; Department of Neurosurgery, BG University Hospital Bergmannsheil, Ruhr-University Bochum, Bochum, Germany.
  • Pleger B; Department of Behavioral Epidemiology, Department of Psychology, Technische Universität Dresden, Dresden, Germany.
JCI Insight ; 4(19)2019 10 03.
Article en En | MEDLINE | ID: mdl-31465301
There is increased interest in whether bariatric surgeries such as Roux-en-Y gastric bypass (RYGB) achieve their profound weight-lowering effects in morbidly obese individuals through the brain. Hypothalamic inflammation is a well-recognized etiologic factor in obesity pathogenesis and so represents a potential target of RYGB, but clinical evidence in support of this is limited. We therefore assessed hypothalamic T2-weighted signal intensities (T2W SI) and fractional anisotropy (FA) values, 2 validated radiologic measures of brain inflammation, in relation to BMI and fat mass, as well as circulating inflammatory (C-reactive protein; CrP) and metabolic markers in a cohort of 27 RYGB patients at baseline and 6 and 12 months after surgery. We found that RYGB progressively increased hypothalamic T2W SI values, while it progressively decreased hypothalamic FA values. Regression analyses further revealed that this could be most strongly linked to plasma CrP levels, which independently predicted hypothalamic FA values when adjusting for age, sex, fat mass, and diabetes diagnosis. These findings suggest that RYGB has a major time-dependent impact on hypothalamic inflammation status, possibly by attenuating peripheral inflammation. They also suggest that hypothalamic FA values may provide a more specific radiologic measure of hypothalamic inflammation than more commonly used T2W SI values.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Obesidad Mórbida / Derivación Gástrica / Hipotálamo / Inflamación Tipo de estudio: Prognostic_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: JCI Insight Año: 2019 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Obesidad Mórbida / Derivación Gástrica / Hipotálamo / Inflamación Tipo de estudio: Prognostic_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: JCI Insight Año: 2019 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos