Your browser doesn't support javascript.
loading
Evidence for default mode network dysfunction in borderline personality disorder.
Aguilar-Ortiz, Salvatore; Salgado-Pineda, Pilar; Vega, Daniel; Pascual, Juan C; Marco-Pallarés, Josep; Soler, Joaquim; Brunel, Cristina; Martin-Blanco, Ana; Soto, Angel; Ribas, Joan; Maristany, Teresa; Sarró, Salvador; Rodríguez-Fornells, Antoni; Salvador, Raymond; McKenna, Peter J; Pomarol-Clotet, Edith.
Afiliación
  • Aguilar-Ortiz S; FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain.
  • Salgado-Pineda P; Benito Menni Complex Assistencial en Salut Mental, Sant Boi de Llobregat, Barcelona, Spain.
  • Vega D; Departament de Psiquiatria i Medicina Legal, PhD Programme, Doctorat en Psiquiatria, Universitat Autònoma de Barcelona (UAB), Barcelona, Spain.
  • Pascual JC; FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain.
  • Marco-Pallarés J; CIBERSAM, Barcelona, Spain.
  • Soler J; Servei de Psiquiatria i Salut Mental, Consorci Sanitari de l'Anoia, Igualada, Spain.
  • Brunel C; CIBERSAM, Barcelona, Spain.
  • Martin-Blanco A; Department of Psychiatry, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
  • Soto A; Faculty of Psychology, University of Barcelona, Bellvitge Hospital, Barcelona, Spain.
  • Ribas J; CIBERSAM, Barcelona, Spain.
  • Maristany T; Department of Psychiatry, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
  • Sarró S; FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain.
  • Rodríguez-Fornells A; Benito Menni Complex Assistencial en Salut Mental, Sant Boi de Llobregat, Barcelona, Spain.
  • Salvador R; Department of Psychiatry, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
  • McKenna PJ; Servei de Psiquiatria i Salut Mental, Consorci Sanitari de l'Anoia, Igualada, Spain.
  • Pomarol-Clotet E; Servei de Psiquiatria i Salut Mental, Consorci Sanitari de l'Anoia, Igualada, Spain.
Psychol Med ; 50(10): 1746-1754, 2020 07.
Article en En | MEDLINE | ID: mdl-31456534
BACKGROUND: Although executive and other cognitive deficits have been found in patients with borderline personality disorder (BPD), whether these have brain functional correlates has been little studied. This study aimed to examine patterns of task-related activation and de-activation during the performance of a working memory task in patients with the disorder. METHODS: Sixty-seven DSM-IV BPD patients and 67 healthy controls underwent fMRI during the performance of the n-back task. Linear models were used to obtain maps of within-group activations and areas of differential activation between the groups. RESULTS: On corrected whole-brain analysis, there were no activation differences between the BPD patients and the healthy controls during the main 2-back v. baseline contrast, but reduced activation was seen in the precentral cortex bilaterally and the left inferior parietal cortex in the 2-back v. 1-back contrast. The patients showed failure of de-activation affecting the medial frontal cortex and the precuneus, plus in other areas. The changes did not appear to be attributable to previous history of depression, which was present in nearly half the sample. CONCLUSIONS: In this study, there was some, though limited, evidence for lateral frontal hypoactivation in BPD during the performance of an executive task. BPD also appears to be associated with failure of de-activation in key regions of the default mode network.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Lóbulo Parietal / Trastorno de Personalidad Limítrofe / Red en Modo Predeterminado Tipo de estudio: Clinical_trials / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male País/Región como asunto: Europa Idioma: En Revista: Psychol Med Año: 2020 Tipo del documento: Article País de afiliación: España Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Lóbulo Parietal / Trastorno de Personalidad Limítrofe / Red en Modo Predeterminado Tipo de estudio: Clinical_trials / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male País/Región como asunto: Europa Idioma: En Revista: Psychol Med Año: 2020 Tipo del documento: Article País de afiliación: España Pais de publicación: Reino Unido