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Development of a Shape-Memory Tube to Prevent Vascular Stenosis.
Shin, Yong Cheol; Lee, Jung Bok; Kim, Dae-Hyun; Kim, Taeyoung; Alexander, Grant; Shin, Young Min; Park, Ju Young; Baek, Sewoom; Yoon, Jeong-Kee; Lee, Yong Jae; Seon, Gyeung Mi; Lee, Mi Hee; Kang, Mi-Lan; Jang, Woo Soon; Park, Jong-Chul; Jun, Ho-Wook; Kim, YongTae; Sung, Hak-Joon.
Afiliación
  • Shin YC; Department of Medical Engineering, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea.
  • Lee JB; Department of Medical Engineering, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea.
  • Kim DH; Department of Medical Engineering, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea.
  • Kim T; George W. Woodruff School of Mechanical Engineering, Wallace H. Coulter Department of Biomedical Engineering, Institute for Electronics and Nanotechnology, Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, 30332, USA.
  • Alexander G; Endomimetics LLC, Birmingham, AL, 35203, USA.
  • Shin YM; Department of Medical Engineering, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea.
  • Park JY; Anas Meditech, Seoul, 08504, Republic of Korea.
  • Baek S; Department of Medical Engineering, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea.
  • Yoon JK; Department of Medical Engineering, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea.
  • Lee YJ; Department of Medical Engineering, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea.
  • Seon GM; Department of Obstetrics and Gynecology, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea.
  • Lee MH; Department of Medical Engineering, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea.
  • Kang ML; Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea.
  • Jang WS; Department of Medical Engineering, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea.
  • Park JC; Department of Medical Engineering, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea.
  • Jun HW; TMD Lab., Seoul, 03722, Republic of Korea.
  • Kim Y; Anas Meditech, Seoul, 08504, Republic of Korea.
  • Sung HJ; Department of Medical Engineering, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea.
Adv Mater ; 31(41): e1904476, 2019 Oct.
Article en En | MEDLINE | ID: mdl-31454108
Inserting a graft into vessels with different diameters frequently causes severe damage to the host vessels. Poor flow patency is an unresolved issue in grafts, particularly those with diameters less than 6 mm, because of vessel occlusion caused by disturbed blood flow following fast clotting. Herein, successful patency in the deployment of an ≈2 mm diameter graft into a porcine vessel is reported. A new library of property-tunable shape-memory polymers that prevent vessel damage by expanding the graft diameter circumferentially upon implantation is presented. The polymers undergo seven consecutive cycles of strain energy-preserved shape programming. Moreover, the new graft tube, which features a diffuser shape, minimizes disturbed flow formation and prevents thrombosis because its surface is coated with nitric-oxide-releasing peptides. Improved patency in a porcine vessel for 18 d is demonstrated while occlusive vascular remodeling occurs. These insights will help advance vascular graft design.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polímeros / Fenómenos Mecánicos / Oclusión de Injerto Vascular Límite: Animals Idioma: En Revista: Adv Mater Asunto de la revista: BIOFISICA / QUIMICA Año: 2019 Tipo del documento: Article Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polímeros / Fenómenos Mecánicos / Oclusión de Injerto Vascular Límite: Animals Idioma: En Revista: Adv Mater Asunto de la revista: BIOFISICA / QUIMICA Año: 2019 Tipo del documento: Article Pais de publicación: Alemania