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Trend level gene-gender interaction effect for the BDNF rs6265 variant on age of onset of psychosis.
Lodhi, Rohit J; Wang, Yabing; Macintyre, Georgina; Crocker, Candice; Loverock, Alexandra; Henriques, Beatriz Carvalho; Heywood, Brodie; Sivapalan, Sudhakar; Bowker, Alexandra; Majeau, Brett; Bolt, Carol; Bugbee, Darren; Newton, Virginia; Tibbo, Philip; Purdon, Scot E; Aitchison, Katherine J.
Afiliación
  • Lodhi RJ; Department of Psychiatry and Medical Genetics, University of Alberta, Edmonton, AB, Canada.
  • Wang Y; Department of Psychiatry and Medical Genetics, University of Alberta, Edmonton, AB, Canada.
  • Macintyre G; Department of Medicine, University of Alberta, Edmonton, AB, Canada.
  • Crocker C; Department of Psychiatry, Dalhousie University, Halifax, NS, Canada.
  • Loverock A; Neuropsychology Department, Alberta Hospital Edmonton, AB, Canada.
  • Henriques BC; Department of Psychiatry and Medical Genetics, University of Alberta, Edmonton, AB, Canada.
  • Heywood B; Department of Psychiatry and Medical Genetics, University of Alberta, Edmonton, AB, Canada.
  • Sivapalan S; Department of Psychiatry and Medical Genetics, University of Alberta, Edmonton, AB, Canada.
  • Bowker A; Neuropsychology Department, Alberta Hospital Edmonton, AB, Canada.
  • Majeau B; Neuropsychology Department, Alberta Hospital Edmonton, AB, Canada.
  • Bolt C; Neuropsychology Department, Alberta Hospital Edmonton, AB, Canada.
  • Bugbee D; Department of Family Medicine, University of Alberta, Edmonton, AB, Canada.
  • Newton V; Neuropsychology Department, Alberta Hospital Edmonton, AB, Canada.
  • Tibbo P; Department of Psychiatry, Dalhousie University, Halifax, NS, Canada; Nova Scotia Early Psychosis Program, Halifax, NS, Canada.
  • Purdon SE; Neuropsychology Department, Alberta Hospital Edmonton, AB, Canada; Edmonton Early Intervention in Psychosis Clinic, Edmonton, AB, Canada.
  • Aitchison KJ; Department of Psychiatry and Medical Genetics, University of Alberta, Edmonton, AB, Canada; Edmonton Early Intervention in Psychosis Clinic, Edmonton, AB, Canada. Electronic address: kaitchis@ualberta.ca.
Psychiatry Res ; 280: 112500, 2019 10.
Article en En | MEDLINE | ID: mdl-31445421
A BDNF rs6265 [A/A] by gender by cannabis use interaction has been associated with age of onset of psychosis (AoP). We examined the gender and cannabis use-adjusted association between BDNF rs6265 [G>A] and AKT1 rs2494732 [T>C] and AoP. Data from 167 Caucasians on AoP and age at first regular cannabis use were collected. Kaplan-Meier and Cox regression analyses were conducted. A trend level gene-gender interaction effect was observed for the BDNF rs6265 A/A genotype, controlling for age at first regular cannabis use. Larger collaborative research projects are required to further investigate this effect.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Psicosis Inducidas por Sustancias / Variación Genética / Fumar Marihuana / Caracteres Sexuales / Factor Neurotrófico Derivado del Encéfalo / Epistasis Genética Tipo de estudio: Diagnostic_studies Aspecto: Determinantes_sociais_saude Límite: Adolescent / Adult / Female / Humans / Male Idioma: En Revista: Psychiatry Res Año: 2019 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Irlanda
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Psicosis Inducidas por Sustancias / Variación Genética / Fumar Marihuana / Caracteres Sexuales / Factor Neurotrófico Derivado del Encéfalo / Epistasis Genética Tipo de estudio: Diagnostic_studies Aspecto: Determinantes_sociais_saude Límite: Adolescent / Adult / Female / Humans / Male Idioma: En Revista: Psychiatry Res Año: 2019 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Irlanda