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Oral Bioavailability of As, Pb, and Cd in Contaminated Soils, Dust, and Foods based on Animal Bioassays: A Review.
Li, Hong-Bo; Li, Meng-Ya; Zhao, Di; Li, Jie; Li, Shi-Wei; Juhasz, Albert L; Basta, Nicholas T; Luo, Yong-Ming; Ma, Lena Q.
Afiliación
  • Li HB; State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment , Nanjing University , Nanjing 210023 , China.
  • Li MY; State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment , Nanjing University , Nanjing 210023 , China.
  • Zhao D; State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment , Nanjing University , Nanjing 210023 , China.
  • Li J; College of Geography and Environment , Shandong Normal University , Jinan 250358 , China.
  • Li SW; School of Water Conservancy and Environment , University of Jinan , Jinan 250022 , China.
  • Juhasz AL; Future Industries Institute , University of South Australia , Mawson Lakes , South Australia 5095 , Australia.
  • Basta NT; School of Environment and Natural Resources , Ohio State University , Columbus , Ohio 43210.
  • Luo YM; Key Laboratory of Soil Environment and Pollution Remediation , Institute of Soil Science, Chinese Academy of Sciences , Nanjing 210008 , China.
  • Ma LQ; State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment , Nanjing University , Nanjing 210023 , China.
Environ Sci Technol ; 53(18): 10545-10559, 2019 Sep 17.
Article en En | MEDLINE | ID: mdl-31442034
Metal contamination in soil, dust, and food matrices impacts the health of millions of people worldwide. During the past decades, various animal bioassays have been developed to determine the relative bioavailability (RBA) of As, Pb, and Cd in contaminated soils, dust, and foods, which vary in operational approaches. This review discusses the strengths and weaknesses of different animal models (swine and mice), dosing schemes (single gavage dose, repeated gavage dose, daily repeated feeding, and free access to diet), and end points (blood, urine, and tissue) in metal-RBA measurement; compares metal-RBA obtained using mouse and swine bioassays, different dosing schemes, and different end points; and summarizes key findings on As-, Pb-, and Cd-RBA values in contaminated soils, dust, and foods. Future directions related to metal-RBA research are highlighted, including (1) comparison of metal-RBA determinations between different bioassays and different laboratories to ensure robust bioavailability data, (2) enhancing the metal-RBA database for contaminated dust and foods, (3) identification of physiological and physicochemical mechanisms responsible for variability in metal-RBA values, (4) formulation of strategies to decrease metal-RBA values in contaminated soils, dust, and foods, and (5) assessing the impacts of cocontaminants on metal-RBA measurement.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Contaminantes del Suelo / Polvo Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Environ Sci Technol Año: 2019 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Contaminantes del Suelo / Polvo Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Environ Sci Technol Año: 2019 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos