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Cingulo-hippocampal effective connectivity positively correlates with drug-cue attentional bias in opioid use disorder.
Ma, Liangsuo; Steinberg, Joel L; Bjork, James M; Taylor, Brian A; Arias, Albert J; Terplan, Mishka; Anastasio, Noelle C; Zuniga, Edward A; Lennon, Michael; Cunningham, Kathryn A; Moeller, F Gerard.
Afiliación
  • Ma L; Institute for Drug and Alcohol Studies, Virginia Commonwealth University, Richmond, VA, USA; Department of Radiology, Virginia Commonwealth University, Richmond, VA, USA. Electronic address: Liangsuo.ma@vcuhealth.org.
  • Steinberg JL; Institute for Drug and Alcohol Studies, Virginia Commonwealth University, Richmond, VA, USA; Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA.
  • Bjork JM; Institute for Drug and Alcohol Studies, Virginia Commonwealth University, Richmond, VA, USA; Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA.
  • Taylor BA; Institute for Drug and Alcohol Studies, Virginia Commonwealth University, Richmond, VA, USA; Department of Biomedical Engineering, Virginia Commonwealth University, Richmond, VA, USA.
  • Arias AJ; Institute for Drug and Alcohol Studies, Virginia Commonwealth University, Richmond, VA, USA; Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA.
  • Terplan M; Institute for Drug and Alcohol Studies, Virginia Commonwealth University, Richmond, VA, USA; Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA.
  • Anastasio NC; Center for Addiction Research and Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX, USA.
  • Zuniga EA; Institute for Drug and Alcohol Studies, Virginia Commonwealth University, Richmond, VA, USA.
  • Lennon M; Center for Translational Science, Virginia Commonwealth University, Richmond, VA, USA.
  • Cunningham KA; Center for Addiction Research and Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX, USA.
  • Moeller FG; Institute for Drug and Alcohol Studies, Virginia Commonwealth University, Richmond, VA, USA; Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA; Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, USA; Department of Neurology, Virgini
Psychiatry Res Neuroimaging ; 294: 110977, 2019 12 30.
Article en En | MEDLINE | ID: mdl-31439409
Individuals with opioid use disorder (OUD) often relapse when exposed to opioid-related cues. Previous functional magnetic resonance imaging (fMRI) studies have identified neuronal corticolimbic changes related to drug cue reactivity in OUD. However, the corresponding manner in which brain regions interact is still unclear. Effective (directional) connectivity was analyzed using dynamic causal modeling of fMRI data acquired from 27 OUD participants (13 with OUD and 14 with OUD and cocaine use disorder [OUD+CUD]), while performing an opioid-word Stroop task. Participants were shown opioid and neutral words presented in different colors and were instructed to indicate word color but ignore word meaning. The effects of opioid words relative to neutral words on effective connectivity and on behavioral reaction time were defined as modulatory change and attentional bias, respectively. For all the 27 participants, left anterior cingulate cortex (ACC) to right hippocampus effective connectivity exhibited the largest modulatory change, which was positively correlated with attentional bias. The findings for the ACC to hippocampus EC were consistent across OUD and CUD found in a previous study.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sesgo Atencional / Giro del Cíngulo / Hipocampo / Trastornos Relacionados con Opioides Tipo de estudio: Prognostic_studies Límite: Female / Humans / Male Idioma: En Revista: Psychiatry Res Neuroimaging Año: 2019 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sesgo Atencional / Giro del Cíngulo / Hipocampo / Trastornos Relacionados con Opioides Tipo de estudio: Prognostic_studies Límite: Female / Humans / Male Idioma: En Revista: Psychiatry Res Neuroimaging Año: 2019 Tipo del documento: Article Pais de publicación: Países Bajos