RAC1B Suppresses TGF-ß-Dependent Chemokinesis and Growth Inhibition through an Autoregulatory Feed-Forward Loop Involving PAR2 and ALK5.

Otterbein, Hannah; Mihara, Koichiro; Hollenberg, Morley D; Lehnert, Hendrik; Witte, David; Ungefroren, Hendrik

Otterbein, Hannah; Mihara, Koichiro; Hollenberg, Morley D; Lehnert, Hendrik; Witte, David; Ungefroren, Hendrik.

Afiliación

Otterbein H; First Department of Medicine, University Hospital Schleswig-Holstein, Campus Lübeck, D-23538 Lübeck, Germany.
Mihara K; Departments of Physiology and Pharmacology and Medicine, Inflammation Research Network, Snyder Institute for Chronic Diseases, University of Calgary, Cumming School of Medicine, Calgary, AB T2N 4N1, Canada.
Hollenberg MD; Departments of Physiology and Pharmacology and Medicine, Inflammation Research Network, Snyder Institute for Chronic Diseases, University of Calgary, Cumming School of Medicine, Calgary, AB T2N 4N1, Canada.
Lehnert H; First Department of Medicine, University Hospital Schleswig-Holstein, Campus Lübeck, D-23538 Lübeck, Germany.
Witte D; First Department of Medicine, University Hospital Schleswig-Holstein, Campus Lübeck, D-23538 Lübeck, Germany. davidwittemail@gmail.com.
Ungefroren H; First Department of Medicine, University Hospital Schleswig-Holstein, Campus Lübeck, D-23538 Lübeck, Germany. hendrik.ungefroren@uksh.de.

Cancers (Basel) ; 11(8)2019 Aug 20.

Article en En | MEDLINE | ID: mdl-31434318

Palabras clave

ALK5; PAR2; RAC1B; RNA interference; TGF-ß; cell migration; pancreatic carcinoma

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Cancers (Basel) Año: 2019 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Suiza

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