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Multifunctional prosthetic polyester-based hybrid mesh for repairing of abdominal wall hernias and defects.
Shokry, Mohamed M; Khalil, Islam A; El-Kasapy, Abdelhaleem; Osman, Ahmed; Mostafa, Ayman; Salah, Mohamed; El-Sherbiny, Ibrahim M.
Afiliación
  • Shokry MM; Department of Surgery, Anesthesiology and Radiology, Faculty of Veterinary Medicine, Cairo University, Giza, 12211, Egypt.
  • Khalil IA; Nanomaterials & Nanomedicine Lab, Center of Material Science (CMS), Zewail City of Science and Technology, 6th of October, Giza, 12588, Egypt; Department of Pharmaceutics and Industrial Pharmacy, College of Pharmacy and Drug Manufacturing, Misr University of Science and Technology (MUST), 6thof
  • El-Kasapy A; Department of Surgery, Faculty of Veterinary Medicine, Benha University, Moshtohor, Egypt.
  • Osman A; Department of Pathology, Faculty of Veterinary Medicine, Cairo University, Giza, 12211, Egypt.
  • Mostafa A; Department of Surgery, Anesthesiology and Radiology, Faculty of Veterinary Medicine, Cairo University, Giza, 12211, Egypt.
  • Salah M; Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Cairo University, Giza, 12211, Egypt.
  • El-Sherbiny IM; Nanomaterials & Nanomedicine Lab, Center of Material Science (CMS), Zewail City of Science and Technology, 6th of October, Giza, 12588, Egypt. Electronic address: ielsherbiny@zewailcity.edu.eg.
Carbohydr Polym ; 223: 115027, 2019 Nov 01.
Article en En | MEDLINE | ID: mdl-31426976
This study involves the design, development and evaluation of a new multifunctional prosthetic mesh for treatment of abdominal wall defects without complications. The developed prosthetic mesh is a hybrid platform of both synthetic and natural materials with its backbone consisting of a synthetic commercial polyester fabric (CPF) to provide the required mechanical integrity. The CPF mesh was coated by a natural biodegradable, biocompatible and antimicrobial layer of chitosan (CS) incorporating phenytoin (PH)-loaded pluronic nanomicelles for healing promotion, and ciprofloxacin (CPX)-alginate polyelectrolyte complex-based microparticles as antibacterial agent. The prosthetic mesh was optimized and evaluated in-vitro and in-vivo. The optimum PH-loaded micelles had particle size of 95.42 nm, polydispersity index of 0.41, zeta potential of -18 and entrapment efficiency of 89.4%, while the optimum CPX microcomplexes had particle size of 1292.0 nm, polydispersity index of 0.8, zeta potential of -20.1, complexation efficiency of 81.1%, and minimum inhibitory concentration of 0.25 µg/ml and 0.125 µg/ml against Staphylococcus aureus and Pseudomonas aeruginosa, respectively. In-vivo study on abdominal wall defect dog model was conducted, followed by implantation of the proposed prosthetic meshes. The developed mesh depicted an efficient healing with excellent biocompatibility, and could be an ideal and feasible alternative prosthesis with many advantages such as low cost, inertness, mechanical stability, pliability, low infection rate, limited modification by body tissues, sterilizability, non-carcinogenicity, limited inflammatory reaction, hypoallergenic as well as minimal complications.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Poliésteres / Prótesis e Implantes / Mallas Quirúrgicas / Pared Abdominal / Hernia Abdominal / Quitosano Límite: Animals Idioma: En Revista: Carbohydr Polym Año: 2019 Tipo del documento: Article País de afiliación: Egipto Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Poliésteres / Prótesis e Implantes / Mallas Quirúrgicas / Pared Abdominal / Hernia Abdominal / Quitosano Límite: Animals Idioma: En Revista: Carbohydr Polym Año: 2019 Tipo del documento: Article País de afiliación: Egipto Pais de publicación: Reino Unido