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Comb-like dextran copolymers: A versatile strategy to coat highly porous MOF nanoparticles with a PEG shell.
Cutrone, Giovanna; Qiu, Jingwen; Menendez-Miranda, Mario; Casas-Solvas, Juan M; Aykaç, Ahmet; Li, Xue; Foulkes, Daniel; Moreira-Alvarez, Borja; Encinar, Jorge R; Ladavière, Catherine; Desmaële, Didier; Vargas-Berenguel, Antonio; Gref, Ruxandra.
Afiliación
  • Cutrone G; Department of Chemistry and Physics, University of Almería, Ctra. de Sacramento s/n, 04120 Almería, Spain.
  • Qiu J; Institut des Sciences Moléculaires d'Orsay, UMR CNRS 8214, Université Paris-Sud, Université Paris Saclay, 91400 Orsay, France.
  • Menendez-Miranda M; Institut des Sciences Moléculaires d'Orsay, UMR CNRS 8214, Université Paris-Sud, Université Paris Saclay, 91400 Orsay, France.
  • Casas-Solvas JM; Department of Chemistry and Physics, University of Almería, Ctra. de Sacramento s/n, 04120 Almería, Spain.
  • Aykaç A; Department of Chemistry and Physics, University of Almería, Ctra. de Sacramento s/n, 04120 Almería, Spain.
  • Li X; Institut des Sciences Moléculaires d'Orsay, UMR CNRS 8214, Université Paris-Sud, Université Paris Saclay, 91400 Orsay, France.
  • Foulkes D; Institut des Sciences Moléculaires d'Orsay, UMR CNRS 8214, Université Paris-Sud, Université Paris Saclay, 91400 Orsay, France.
  • Moreira-Alvarez B; Department of Physical and Analytical Chemistry, University of Oviedo, Julián Clavería 8, 33006 Oviedo, Spain.
  • Encinar JR; Department of Physical and Analytical Chemistry, University of Oviedo, Julián Clavería 8, 33006 Oviedo, Spain.
  • Ladavière C; University of Lyon, CNRS, UMR 5223, IMP, 15 bd André Latarjet, F-69622 Villeurbanne, France.
  • Desmaële D; Institut Galien Paris-Sud, UMR 8612, CNRS, Université Paris-Sud, Faculté de Pharmacie, 5 rue JB Clément, 92296 Châtenay-Malabry, France.
  • Vargas-Berenguel A; Department of Chemistry and Physics, University of Almería, Ctra. de Sacramento s/n, 04120 Almería, Spain. Electronic address: avargas@ual.es.
  • Gref R; Institut des Sciences Moléculaires d'Orsay, UMR CNRS 8214, Université Paris-Sud, Université Paris Saclay, 91400 Orsay, France. Electronic address: ruxandra.gref@u-psud.fr.
Carbohydr Polym ; 223: 115085, 2019 Nov 01.
Article en En | MEDLINE | ID: mdl-31426973
Nanoparticles made of metal-organic frameworks (nanoMOFs) are becoming of increasing interest as drug carriers. However, engineered coatings such as poly(ethylene glycol) (PEG) based ones are required to prevent nanoMOFs recognition and clearance by the innate immune system, a prerequisite for biomedical applications. This still presents an important challenge due to the highly porous structure and degradability of nanoMOFs. We provide here a proof of concept that the surface of iron-based nanoMOFs can be functionalized in a rapid, organic solvent-free and non-covalent manner using a novel family of comb-like copolymers made of dextran (DEX) grafted with both PEG and alendronate (ALN) moieties, which are iron complexing groups to anchor to the nanoMOFs surface. We describe the synthesis of DEX-ALN-PEG copolymers by click chemistry, with control of both the amount of PEG and ALN moieties. Stable DEX-ALN-PEG coatings substantially decreased their internalization by macrophages in vitro, providing new perspectives for biomedical applications.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Carbohydr Polym Año: 2019 Tipo del documento: Article País de afiliación: España Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Carbohydr Polym Año: 2019 Tipo del documento: Article País de afiliación: España Pais de publicación: Reino Unido