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Ultrasensitive Detection of Plasma Amyloid-ß as a Biomarker for Cognitively Normal Elderly Individuals at Risk of Alzheimer's Disease.
Chatterjee, Pratishtha; Elmi, Mitra; Goozee, Kathryn; Shah, Tejal; Sohrabi, Hamid R; Dias, Cintia B; Pedrini, Steve; Shen, Kaikai; Asih, Prita R; Dave, Preeti; Taddei, Kevin; Vanderstichele, Hugo; Zetterberg, Henrik; Blennow, Kaj; Martins, Ralph N.
Afiliación
  • Chatterjee P; Department of Biomedical Sciences, Macquarie University, North Ryde, NSW, Australia.
  • Elmi M; School of Medical Health and Sciences, Edith Cowan University, Joondalup, WA, Australia.
  • Goozee K; Department of Biomedical Sciences, Macquarie University, North Ryde, NSW, Australia.
  • Shah T; Department of Biomedical Sciences, Macquarie University, North Ryde, NSW, Australia.
  • Sohrabi HR; School of Medical Health and Sciences, Edith Cowan University, Joondalup, WA, Australia.
  • Dias CB; KaRa Institute of Neurological Disease, Sydney, Macquarie Park, Australia.
  • Pedrini S; Anglicare, Sydney, Castle Hill, NSW, Australia.
  • Shen K; School of Psychiatry and Clinical Neurosciences, University of Western Australia, Crawley, WA, Australia.
  • Asih PR; The Cooperative Research Centre for Mental Health, Carlton South, Australia.
  • Dave P; Department of Biomedical Sciences, Macquarie University, North Ryde, NSW, Australia.
  • Taddei K; School of Medical Health and Sciences, Edith Cowan University, Joondalup, WA, Australia.
  • Vanderstichele H; Australian Alzheimer's Research Foundation, Nedlands, WA, Australia.
  • Zetterberg H; Department of Biomedical Sciences, Macquarie University, North Ryde, NSW, Australia.
  • Blennow K; School of Medical Health and Sciences, Edith Cowan University, Joondalup, WA, Australia.
  • Martins RN; School of Psychiatry and Clinical Neurosciences, University of Western Australia, Crawley, WA, Australia.
J Alzheimers Dis ; 71(3): 775-783, 2019.
Article en En | MEDLINE | ID: mdl-31424403
BACKGROUND: Aberrant amyloid-ß (Aß) deposition in the brain occurs two decades prior to the manifestation of Alzheimer's disease (AD) clinical symptoms and therefore brain Aß load measured using PET serves as a gold standard biomarker for the early diagnosis of AD. However, the uneconomical nature of PET makes blood markers, that reflect brain Aß deposition, attractive candidates for investigation as surrogate markers. OBJECTIVE: Investigation of plasma Aß as a surrogate marker for brain Aß deposition in cognitively normal elderly individuals. METHODS: Plasma Aß40 and Aß42 concentrations were measured using the ultrasensitive Single Molecule Array (Simoa) assay in 95 cognitively normal elderly individuals, who have all undergone PET to assess brain Aß deposition. Based on the standard uptake value ratios (SUVR) obtained from PET imaging, using the tracer 18F-Florbetaben, plasma Aß was compared between 32 participants assessed to have low brain Aß load (Aß-, SUVR <1.35) and 63 assessed to have high brain Aß load (Aß+, SUVR ≥1.35). RESULTS: Plasma Aß42/Aß40 ratios were lower in the Aß+ group compared to the Aß-group. Plasma Aß40 and Aß42 levels were not significantly different between Aß-and Aß+ groups, although a trend of higher plasma Aß40 was observed in the Aß+ group. Additionally, plasma Aß42/Aß40 ratios along with the known AD risk factors, age and APOEɛ4 status, resulted in Aß+ participants being distinguished from Aß-participants based on an area under the receiver operating characteristic curve shown to be 78%. CONCLUSION: Plasma Aß ratios in this study are a potential biomarker for brain Aß deposition and therefore, for preclinical AD. However, this method to measure plasma Aß needs further development to increase the accuracy of this promising AD blood biomarker.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Biomarcadores / Péptidos beta-Amiloides / Cognición / Enfermedad de Alzheimer Tipo de estudio: Diagnostic_studies / Etiology_studies / Risk_factors_studies / Screening_studies Límite: Aged / Aged80 / Female / Humans / Male Idioma: En Revista: J Alzheimers Dis Asunto de la revista: GERIATRIA / NEUROLOGIA Año: 2019 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Biomarcadores / Péptidos beta-Amiloides / Cognición / Enfermedad de Alzheimer Tipo de estudio: Diagnostic_studies / Etiology_studies / Risk_factors_studies / Screening_studies Límite: Aged / Aged80 / Female / Humans / Male Idioma: En Revista: J Alzheimers Dis Asunto de la revista: GERIATRIA / NEUROLOGIA Año: 2019 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Países Bajos