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Combination antifungals as an effective means of salvage in paediatric leukaemia patients with invasive fungal infections.
Meena, Jagdish Prasad; Gupta, Aditya Kumar; Jana, Manisha; Seth, Rachna.
Afiliación
  • Meena JP; Department of Pediatrics, Division of Pediatric Oncology, All Institute of Medical Sciences, New Delhi, India.
  • Gupta AK; Department of Pediatrics, Division of Pediatric Oncology, All Institute of Medical Sciences, New Delhi, India.
  • Jana M; Department of Radiology, All Institute of Medical Sciences, New Delhi, India.
  • Seth R; Department of Pediatrics, Division of Pediatric Oncology, All Institute of Medical Sciences, New Delhi, India.
Indian J Med Microbiol ; 37(1): 109-112, 2019.
Article en En | MEDLINE | ID: mdl-31424020
Invasive fungal infections (IFIs) are an important cause of morbidity and mortality in paediatric leukaemias. Antifungal combinations to treat these patients are being explored. Fourteen children with leukaemias and IFIs were treated with a combination of antifungal agents at our centre. The first antifungal was amphotericin-B in 13 children and voriconazole in one child. In view of no improvement and clinical deterioration, in nine patients, voriconazole was added as the second antifungal agent and in four, it was caspofungin. All patients completed 4-6 weeks of antifungal therapy. The overall mortality attributable to IFI for the cohort was 4/14 (28%).
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Anfotericina B / Voriconazol / Infecciones Fúngicas Invasoras / Caspofungina / Antifúngicos Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Adolescent / Child / Child, preschool / Female / Humans / Male Idioma: En Revista: Indian J Med Microbiol Asunto de la revista: MICROBIOLOGIA Año: 2019 Tipo del documento: Article País de afiliación: India Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Anfotericina B / Voriconazol / Infecciones Fúngicas Invasoras / Caspofungina / Antifúngicos Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Adolescent / Child / Child, preschool / Female / Humans / Male Idioma: En Revista: Indian J Med Microbiol Asunto de la revista: MICROBIOLOGIA Año: 2019 Tipo del documento: Article País de afiliación: India Pais de publicación: Estados Unidos