Downregulation of eukaryotic translation initiation factor 3b inhibited proliferation and metastasis of gastric cancer.

Ma, Fang; Li, Xue; Ren, Juchao; Guo, Ruiting; Li, Yuwei; Liu, Jichang; Sun, Yundong; Liu, Zhifang; Jia, Jihui; Li, Wenjuan

Ma, Fang; Li, Xue; Ren, Juchao; Guo, Ruiting; Li, Yuwei; Liu, Jichang; Sun, Yundong; Liu, Zhifang; Jia, Jihui; Li, Wenjuan.

Afiliación

Ma F; Key Laboratory for Experimental Teratology of Chinese Ministry of Education, The Shandong Provincial Key Laboratory of Infection and Immunology, Department of Microbiology, School of basic medical sciences, Shandong University-Karolinska Institutet Collaborative Laboratory for Cancer Research, Shand
Li X; Key Laboratory for Experimental Teratology of Chinese Ministry of Education, The Shandong Provincial Key Laboratory of Infection and Immunology, Department of Microbiology, School of basic medical sciences, Shandong University-Karolinska Institutet Collaborative Laboratory for Cancer Research, Shand
Ren J; Department of Urology, Qilu Hospital, Shandong University, Jinan, PR China.
Guo R; Key Laboratory for Experimental Teratology of Chinese Ministry of Education, The Shandong Provincial Key Laboratory of Infection and Immunology, Department of Microbiology, School of basic medical sciences, Shandong University-Karolinska Institutet Collaborative Laboratory for Cancer Research, Shand
Li Y; Key Laboratory for Experimental Teratology of Chinese Ministry of Education, The Shandong Provincial Key Laboratory of Infection and Immunology, Department of Microbiology, School of basic medical sciences, Shandong University-Karolinska Institutet Collaborative Laboratory for Cancer Research, Shand
Liu J; Key Laboratory for Experimental Teratology of Chinese Ministry of Education, The Shandong Provincial Key Laboratory of Infection and Immunology, Department of Microbiology, School of basic medical sciences, Shandong University-Karolinska Institutet Collaborative Laboratory for Cancer Research, Shand
Sun Y; Key Laboratory for Experimental Teratology of Chinese Ministry of Education, The Shandong Provincial Key Laboratory of Infection and Immunology, Department of Microbiology, School of basic medical sciences, Shandong University-Karolinska Institutet Collaborative Laboratory for Cancer Research, Shand
Liu Z; Department of Biochemistry and Molecular Biology, School of basic medical sciences, Shandong University, Jinan, PR China.
Jia J; Key Laboratory for Experimental Teratology of Chinese Ministry of Education, The Shandong Provincial Key Laboratory of Infection and Immunology, Department of Microbiology, School of basic medical sciences, Shandong University-Karolinska Institutet Collaborative Laboratory for Cancer Research, Shand
Li W; Key Laboratory for Experimental Teratology of Chinese Ministry of Education, The Shandong Provincial Key Laboratory of Infection and Immunology, Department of Microbiology, School of basic medical sciences, Shandong University-Karolinska Institutet Collaborative Laboratory for Cancer Research, Shand

Cell Death Dis ; 10(9): 623, 2019 08 19.

Article en En | MEDLINE | ID: mdl-31423012

RESUMEN

Eukaryotic translation initiation factor 3 (eIF3) plays an important role in the regulation of mRNA translation, cell growth and cancer development. eIF3b is the main scaffolding subunit in the eIF3 complex and has been demonstrated to contribute to the development of several cancers. First, our study found that the downregulation of eIF3b could inhibit the proliferation and metastasis of gastric cancer cells by regulating the expression of cancer-related genes. In addition, the expression of eIF3b correlated with the stage and progression of gastric cancer and was shown to be upregulated in human chronic gastritis and in gastric cancer tissues compared with the expression of eIF3b in normal gastric tissues. Moreover, Helicobacter pylori (H. pylori) infection could upregulate the expression of eIF3b in gastric cancer cells, suggesting that eIF3b might be involved in the carcinogenic process of H. pylori. The above findings identified the oncogenic role of eIF3b in gastric cancer development, and this may contribute to the exploration and discovery of novel therapeutic targets for gastric cancer treatment.

Asunto(s)

Factor 3 de Iniciación Eucariótica/biosíntesis; Neoplasias Gástricas/metabolismo; Animales; Antígenos Bacterianos/genética; Antígenos Bacterianos/metabolismo; Proteínas Bacterianas/genética; Proteínas Bacterianas/metabolismo; Línea Celular Tumoral; Proliferación Celular/fisiología; Progresión de la Enfermedad; Regulación hacia Abajo; Factor 3 de Iniciación Eucariótica/genética; Factor 3 de Iniciación Eucariótica/metabolismo; Femenino; Gastritis/genética; Gastritis/metabolismo; Gastritis/patología; Infecciones por Helicobacter/genética; Infecciones por Helicobacter/metabolismo; Infecciones por Helicobacter/patología; Helicobacter pylori/genética; Helicobacter pylori/metabolismo; Xenoinjertos; Humanos; Ratones; Ratones Endogámicos BALB C; Ratones Desnudos; Metástasis de la Neoplasia; ARN Mensajero/biosíntesis; ARN Mensajero/genética; ARN Mensajero/metabolismo; ARN Interferente Pequeño/administración & dosificación; ARN Interferente Pequeño/genética; Transducción de Señal/genética; Neoplasias Gástricas/genética; Neoplasias Gástricas/microbiología; Neoplasias Gástricas/patología; Transfección

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Gástricas / Factor 3 de Iniciación Eucariótica Tipo de estudio: Prognostic_studies Idioma: En Revista: Cell Death Dis Año: 2019 Tipo del documento: Article Pais de publicación: Reino Unido

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