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Recent prescription status of oral analgesics in Japan in real-world clinical settings: retrospective study using a large-scale prescription database.
Ushida, Takahiro; Matsui, Daiju; Inoue, Teruyoshi; Yokoyama, Mizuka; Takatsuna, Hiroshi; Matsumoto, Takuyuki; Takita, Atsushi; Kurusu, Takao; Sakoda, Hiroshi; Okuizumi, Kaoru.
Afiliación
  • Ushida T; Multidisciplinary Pain Center, Aichi Medical University , Aichi , Japan.
  • Matsui D; Medical Affairs Division, Medical Science Department, Daiichi Sankyo Co., Ltd ., Tokyo , Japan.
  • Inoue T; Medical Affairs Division, Medical Science Department, Daiichi Sankyo Co., Ltd ., Tokyo , Japan.
  • Yokoyama M; Medical Affairs Division, Medical Science Department, Daiichi Sankyo Co., Ltd ., Tokyo , Japan.
  • Takatsuna H; Medical Affairs Division, Medical Science Department, Daiichi Sankyo Co., Ltd ., Tokyo , Japan.
  • Matsumoto T; Quality & Safety Management Division, Safety and Risk Management Department, Daiichi Sankyo Co., Ltd ., Tokyo , Japan.
  • Takita A; R&D Division, Biostatistics & Data Management Department, Daiichi Sankyo Co., Ltd ., Tokyo , Japan.
  • Kurusu T; Rx Group, Data Solution Division, Japan Medical Information Research Institute, Inc ., Tokyo , Japan.
  • Sakoda H; Medical Affairs Division, Medical Science Department, Daiichi Sankyo Co., Ltd ., Tokyo , Japan.
  • Okuizumi K; Medical Affairs Division, Medical Science Department, Daiichi Sankyo Co., Ltd ., Tokyo , Japan.
Expert Opin Pharmacother ; 20(16): 2041-2052, 2019 Nov.
Article en En | MEDLINE | ID: mdl-31422709
Background: Information on prescriptions of oral analgesics for the treatment of pain is beneficial. However, there have been few reports on the prescription status of oral analgesics from a nation-wide, large-scale prescription database in Japan. Research design and methods: The authors analyzed the prescription data of 2,042,302 patients prescribed oral analgesics in 2017. The numbers/proportions of patients prescribed oral analgesics, adherence with approved doses, co-prescription patterns, dose changes, drug adherence, and treatment-discontinuation rates were evaluated. Results: Loxoprofen was prescribed to 32.5% of the patients, followed by celecoxib, prescribed to 16.0% of patients. Acetaminophen and pregabalin were prescribed to 10.5% and 9.4% of patients, respectively. Many analgesics were prescribed at lower doses than the approved doses. The most frequently used concomitant medication was pregabalin. For duloxetine and pregabalin, high proportions of patients were prescribed these drugs for > 90 days. Conclusions: Loxoprofen was the most prescribed of the non-steroidal anti-inflammatory drugs in Japan. The information obtained provides an overview of prescribed oral analgesics in Japan and could be useful for potential research into prescribed oral analgesics in the future.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Dolor / Prescripciones / Analgésicos Tipo de estudio: Observational_studies Límite: Adolescent / Adult / Aged / Child / Child, preschool / Female / Humans / Infant / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: Expert Opin Pharmacother Asunto de la revista: FARMACOLOGIA Año: 2019 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Dolor / Prescripciones / Analgésicos Tipo de estudio: Observational_studies Límite: Adolescent / Adult / Aged / Child / Child, preschool / Female / Humans / Infant / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: Expert Opin Pharmacother Asunto de la revista: FARMACOLOGIA Año: 2019 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido