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Molecular aspects of delta opioid receptors.
Gendron, Louis; Nagi, Karim; Zeghal, Manel; Giguère, Patrick M; Pineyro, Graciela.
Afiliación
  • Gendron L; Department of Pharmacology-Physiology, Université de Sherbrooke, Centre de Recherche du CHUS, Sherbrooke, QC, Canada; Quebec Pain Research Network, Sherbrooke, QC, Canada. Electronic address: louis.gendron@usherbrooke.ca.
  • Nagi K; College of Medicine, Member of QU Health, Qatar University, Doha, Qatar.
  • Zeghal M; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada; Brain and Mind Research Institute, University of Ottawa, Ottawa, ON, Canada.
  • Giguère PM; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada; Brain and Mind Research Institute, University of Ottawa, Ottawa, ON, Canada.
  • Pineyro G; CHU Sainte-Justine research center, Department of Pharmacology, Faculty of Medicine, University of Montreal, Montreal, QC, Canada; Quebec Pain Research Network, Sherbrooke, QC, Canada.
Vitam Horm ; 111: 49-90, 2019.
Article en En | MEDLINE | ID: mdl-31421707
The delta opioid receptor (DOP) belongs to the Class A, rhodopsin-like family of G protein-coupled receptors. Although this receptor has a high level of similarity with the other opioid receptors, it displays unique aspects and functions. Indeed, as opposed to most membrane receptors, DOP is poorly addressed to the plasma membrane. In this chapter, we first review the molecular and cellular mechanisms regulating the expression and the cellular trafficking/sorting of DOP. We then summarize the structural insights of this receptor through the analysis of the existing crystal structures, with a particular focus on the role of the sodium binding site. Finally, we review the current signaling mechanisms mediating receptor function and desensitization.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Receptores Opioides delta Límite: Animals / Humans Idioma: En Revista: Vitam Horm Año: 2019 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Receptores Opioides delta Límite: Animals / Humans Idioma: En Revista: Vitam Horm Año: 2019 Tipo del documento: Article Pais de publicación: Estados Unidos