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Epidemiology of invasive meningococcal disease in Greece, 2006-2016.
Flountzi, Anastasia; Georgakopoulou, Theano; Balasegaram, Sooria; Kesanopoulos, Konstantinos; Xirogianni, Athanasia; Papandreou, Anastasia; Tzanakaki, Georgina.
Afiliación
  • Flountzi A; European Programme for Public Health Microbiology Training (EUPHEM), European Centre for Disease Prevention and Control (ECDC), Stockholm, Sweden.
  • Georgakopoulou T; Department of Public Health Policy, School of Public Health, University of West Attica/Hellenic Center for Disease Control and Prevention (HCDC), Athens, Greece.
  • Balasegaram S; Department of Epidemiological Surveillance and Intervention of the National Public Health Organization (NPHO), Athens, Greece.
  • Kesanopoulos K; National Infection Service, Public Health England, London, UK.
  • Xirogianni A; National Meningitis Reference Laboratory, Department of Public Health Policy, School of Public Health, University of West Attica, 196, Alexandras Avenue, Athens, Greece.
  • Papandreou A; National Meningitis Reference Laboratory, Department of Public Health Policy, School of Public Health, University of West Attica, 196, Alexandras Avenue, Athens, Greece.
  • Tzanakaki G; National Meningitis Reference Laboratory, Department of Public Health Policy, School of Public Health, University of West Attica, 196, Alexandras Avenue, Athens, Greece.
Eur J Clin Microbiol Infect Dis ; 38(12): 2197-2203, 2019 Dec.
Article en En | MEDLINE | ID: mdl-31418100
The present study describes the epidemiology of invasive meningococcal disease (IMD) in Greece for the period 2006-2016. Combined data from notified and laboratory-confirmed IMD cases were obtained from the two involved National Centres (Epidemiology and Reference Laboratory). Laboratory identification and typing was carried out by both conventional (culture) and molecular methods (PCR, MLST, PorA, and FetA typing). A total of 796 IMD cases were notified; of those, 720 (91%) were laboratory confirmed. Overall, a decline on the annual incidence of confirmed cases was observed, ranging from 0.91 (2006) to 0.47 (2016) /100,000. A similar trend was observed in most age groups especially in children 0-4 years (7.7 to 2.9/100,000), with the exception of an increase in the incidence rate in adults > 20 years (0.21 to 0.32/100,000). The overall case fatality rate was 6.5% (52/796), annual range 2-13%. Among 658 strains which were typed by sero/genogroup, 80% were identified as MenB (annual range 65-92%); however, a decline was observed in MenB incidence from 5.3 (2006) to 2.7 (2016), among infants and toddlers, while MenW (1%), MenY (2%), and MenA (1%) remained low. During the 11 years, the annual incidence of IMD declined by 50%, especially in the 0-4-year age group, due mainly to MenB. Continuous surveillance of IMD is important for the development of future vaccination and public health policies.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones Meningocócicas Tipo de estudio: Diagnostic_studies / Incidence_studies / Prognostic_studies / Screening_studies Límite: Humans País/Región como asunto: Europa Idioma: En Revista: Eur J Clin Microbiol Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS / MICROBIOLOGIA Año: 2019 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones Meningocócicas Tipo de estudio: Diagnostic_studies / Incidence_studies / Prognostic_studies / Screening_studies Límite: Humans País/Región como asunto: Europa Idioma: En Revista: Eur J Clin Microbiol Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS / MICROBIOLOGIA Año: 2019 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Alemania