Class Id ribonucleotide reductase utilizes a Mn<sub>2</sub>(IV,III) cofactor and undergoes large conformational changes on metal loading.

Rozman Grinberg, Inna; Berglund, Sigrid; Hasan, Mahmudul; Lundin, Daniel; Ho, Felix M; Magnuson, Ann; Logan, Derek T; Sjöberg, Britt-Marie; Berggren, Gustav

Class Id ribonucleotide reductase utilizes a Mn₂(IV,III) cofactor and undergoes large conformational changes on metal loading.

Rozman Grinberg, Inna; Berglund, Sigrid; Hasan, Mahmudul; Lundin, Daniel; Ho, Felix M; Magnuson, Ann; Logan, Derek T; Sjöberg, Britt-Marie; Berggren, Gustav.

Afiliación

Rozman Grinberg I; Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden.
Berglund S; Department of Chemistry, Ångström Laboratory, Uppsala University, Uppsala, Sweden.
Hasan M; Department of Biochemistry and Structural Biology, Lund University, Lund, Sweden.
Lundin D; Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden.
Ho FM; Department of Chemistry, Ångström Laboratory, Uppsala University, Uppsala, Sweden.
Magnuson A; Department of Chemistry, Ångström Laboratory, Uppsala University, Uppsala, Sweden.
Logan DT; Department of Biochemistry and Structural Biology, Lund University, Lund, Sweden. derek.logan@biochemistry.lu.se.
Sjöberg BM; Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden. britt-marie.sjoberg@dbb.su.se.
Berggren G; Department of Chemistry, Ångström Laboratory, Uppsala University, Uppsala, Sweden. gustav.berggren@kemi.uu.se.

J Biol Inorg Chem ; 24(6): 863-877, 2019 09.

Article en En | MEDLINE | ID: mdl-31414238

Asunto(s)

Manganeso/metabolismo; Ribonucleótido Reductasas/metabolismo; Aerococcaceae/metabolismo; Cristalografía por Rayos X; Espectroscopía de Resonancia por Spin del Electrón; Flavobacteriaceae/metabolismo; Radicales Libres/metabolismo; Peróxido de Hidrógeno/metabolismo; Oxidación-Reducción; Ribonucleótido Reductasas/química; Ribonucleótido Reductasas/genética; Superóxidos/metabolismo

Palabras clave

Dimanganese cofactor; Electron paramagnetic resonance; Phylogeny; Radicals; Ribonucleotide reductase; X-ray crystallography

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ribonucleótido Reductasas / Manganeso Idioma: En Revista: J Biol Inorg Chem Asunto de la revista: BIOQUIMICA Año: 2019 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Alemania

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