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Radiofrequency Ablation Duration per Tumor Volume May Correlate with Overall Survival in Solitary Hepatocellular Carcinoma Patients Treated with Radiofrequency Ablation Plus Lyso-Thermosensitive Liposomal Doxorubicin.
Celik, Haydar; Wakim, Paul; Pritchard, William F; Castro, Meryll; Leonard, Shelby; Karanian, John W; Dewhirst, Mark W; Lencioni, Riccardo; Wood, Bradford J.
Afiliación
  • Celik H; Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, 9000 Rockville Pike, Building 10, Room 3N320, Bethesda, MD 20892. Electronic address: haydar.celik@nih.gov.
  • Wakim P; Biostatistics and Clinical Epidemiology Service, Clinical Center, National Institutes of Health, 9000 Rockville Pike, Building 10, Room 3N320, Bethesda, MD 20892.
  • Pritchard WF; Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, 9000 Rockville Pike, Building 10, Room 3N320, Bethesda, MD 20892.
  • Castro M; Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, 9000 Rockville Pike, Building 10, Room 3N320, Bethesda, MD 20892.
  • Leonard S; Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, 9000 Rockville Pike, Building 10, Room 3N320, Bethesda, MD 20892.
  • Karanian JW; Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, 9000 Rockville Pike, Building 10, Room 3N320, Bethesda, MD 20892.
  • Dewhirst MW; Duke Cancer Institute, Duke University, Durham, North Carolina.
  • Lencioni R; Division of Diagnostic Imaging and Intervention, Pisa University School of Medicine, Pisa, Italy.
  • Wood BJ; Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, 9000 Rockville Pike, Building 10, Room 3N320, Bethesda, MD 20892.
J Vasc Interv Radiol ; 30(12): 1908-1914, 2019 Dec.
Article en En | MEDLINE | ID: mdl-31409568
PURPOSE: To determine whether burn time per tumor volume (BPV) (min/mL), where burn time is the total time during which radiofrequency (RF) energy is being applied, is correlated with hepatocellular carcinoma (HCC) treatment outcomes using RF ablation and lyso-thermosensitive liposomal doxorubicin (LTLD). MATERIALS AND METHODS: The HEAT study was a double-blind, randomized controlled phase III trial of RF ablation only versus RF ablation + LTLD in patients with HCCs 3-7 cm in diameter. Effect of BPV on progression-free survival and overall survival (OS) was analyzed. RESULTS: BPV demonstrated statistically significant differences between study groups for OS (P = .038, hazard ratio [HR] = 0.85), but not for progression-free survival (P = .389, HR = 1.059). In a separate analysis, treatment groups were independently analyzed to determine the effect of BPV within each individual group. OS improved as BPV increased for patients receiving RF ablation + LTLD (P = .017, HR = 0.836, confidence interval [0.722, 0.968]). This same association was not observed in patients receiving RF ablation only (P = .57, HR = 0.99). CONCLUSIONS: BPV may be a useful metric for RF ablation + LTLD combination therapy for solitary HCC. The analysis suggested that the burn time for the tumor needs to be adjusted depending on the tumor volume. Because this is a post hoc study, the results are only suggestive and need to be confirmed with prospective studies.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Doxorrubicina / Carcinoma Hepatocelular / Carga Tumoral / Tempo Operativo / Ablación por Radiofrecuencia / Neoplasias Hepáticas / Antibióticos Antineoplásicos Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: J Vasc Interv Radiol Asunto de la revista: ANGIOLOGIA / RADIOLOGIA Año: 2019 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Doxorrubicina / Carcinoma Hepatocelular / Carga Tumoral / Tempo Operativo / Ablación por Radiofrecuencia / Neoplasias Hepáticas / Antibióticos Antineoplásicos Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: J Vasc Interv Radiol Asunto de la revista: ANGIOLOGIA / RADIOLOGIA Año: 2019 Tipo del documento: Article Pais de publicación: Estados Unidos