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Generation of Human Fatty Livers Using Custom-Engineered Induced Pluripotent Stem Cells with Modifiable SIRT1 Metabolism.
Collin de l'Hortet, Alexandra; Takeishi, Kazuki; Guzman-Lepe, Jorge; Morita, Kazutoyo; Achreja, Abhinav; Popovic, Branimir; Wang, Yang; Handa, Kan; Mittal, Anjali; Meurs, Noah; Zhu, Ziwen; Weinberg, Frank; Salomon, Michael; Fox, Ira J; Deng, Chu-Xia; Nagrath, Deepak; Soto-Gutierrez, Alejandro.
Afiliación
  • Collin de l'Hortet A; Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA.
  • Takeishi K; Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA; Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
  • Guzman-Lepe J; Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA.
  • Morita K; Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA.
  • Achreja A; Department of Biomedical Engineering, University of Michigan Biomedical Engineering, Ann Arbor, MI, USA; Biointerfaces Institute, University of Michigan, Ann Arbor, MI, USA.
  • Popovic B; Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA.
  • Wang Y; Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA; Department of Hepatobiliary Surgery, Peking University People's Hospital, Beijing, China.
  • Handa K; Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA.
  • Mittal A; Biointerfaces Institute, University of Michigan, Ann Arbor, MI, USA; Department of Chemical Engineering, University of Michigan, Ann Arbor, MI, USA.
  • Meurs N; Department of Biomedical Engineering, University of Michigan Biomedical Engineering, Ann Arbor, MI, USA; Biointerfaces Institute, University of Michigan, Ann Arbor, MI, USA.
  • Zhu Z; Department of Biomedical Engineering, University of Michigan Biomedical Engineering, Ann Arbor, MI, USA; Biointerfaces Institute, University of Michigan, Ann Arbor, MI, USA.
  • Weinberg F; Division of Hematology/Oncology, Department of Internal Medicine, University of Michigan Rogel Cancer Center, Ann Arbor, MI, USA.
  • Salomon M; Sirion Biotech, Am Klopferspitz 19, 82152 Planegg, Germany.
  • Fox IJ; Department of Surgery, Children's Hospital of Pittsburgh of UPMC, University of Pittsburgh, Pittsburgh, PA, USA.
  • Deng CX; Faculty of Health Sciences, University of Macau, Avenida da Universidade, Taipa, Macau, China.
  • Nagrath D; Department of Biomedical Engineering, University of Michigan Biomedical Engineering, Ann Arbor, MI, USA; Biointerfaces Institute, University of Michigan, Ann Arbor, MI, USA; Department of Chemical Engineering, University of Michigan, Ann Arbor, MI, USA; Rogel Cancer Center, University of Michigan, A
  • Soto-Gutierrez A; Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address: als208@pitt.edu.
Cell Metab ; 30(2): 385-401.e9, 2019 08 06.
Article en En | MEDLINE | ID: mdl-31390551
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células Madre Pluripotentes / Hígado Graso / Sirtuina 1 / Ingeniería Celular Límite: Adult / Animals / Humans / Male Idioma: En Revista: Cell Metab Asunto de la revista: METABOLISMO Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células Madre Pluripotentes / Hígado Graso / Sirtuina 1 / Ingeniería Celular Límite: Adult / Animals / Humans / Male Idioma: En Revista: Cell Metab Asunto de la revista: METABOLISMO Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos