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Synaptotagmin 17 controls neurite outgrowth and synaptic physiology via distinct cellular pathways.
Ruhl, David A; Bomba-Warczak, Ewa; Watson, Emma T; Bradberry, Mazdak M; Peterson, Tabitha A; Basu, Trina; Frelka, Alyssa; Evans, Chantell S; Briguglio, Joseph S; Basta, Tamara; Stowell, Michael H B; Savas, Jeffrey N; Roopra, Avtar; Pearce, Robert A; Piper, Robert C; Chapman, Edwin R.
Afiliación
  • Ruhl DA; Department of Neuroscience, University of Wisconsin, Madison, WI, 53706, USA.
  • Bomba-Warczak E; Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.
  • Watson ET; Department of Neuroscience, University of Wisconsin, Madison, WI, 53706, USA.
  • Bradberry MM; Department of Neuroscience, University of Wisconsin, Madison, WI, 53706, USA.
  • Peterson TA; Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, IA, 52242, USA.
  • Basu T; Department of Neuroscience, University of Wisconsin, Madison, WI, 53706, USA.
  • Frelka A; Department of Anesthesiology, University of Wisconsin, Madison, WI, 53706, USA.
  • Evans CS; Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
  • Briguglio JS; Department of Neuroscience, University of Wisconsin, Madison, WI, 53706, USA.
  • Basta T; Department of Molecular, Cellular and Developmental Biology, University of Colorado at Boulder, Boulder, CO, 80309, USA.
  • Stowell MHB; Department of Molecular, Cellular and Developmental Biology, University of Colorado at Boulder, Boulder, CO, 80309, USA.
  • Savas JN; Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.
  • Roopra A; Department of Neuroscience, University of Wisconsin, Madison, WI, 53706, USA.
  • Pearce RA; Department of Anesthesiology, University of Wisconsin, Madison, WI, 53706, USA.
  • Piper RC; Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, IA, 52242, USA.
  • Chapman ER; Department of Neuroscience, University of Wisconsin, Madison, WI, 53706, USA. chapman@wisc.edu.
Nat Commun ; 10(1): 3532, 2019 08 06.
Article en En | MEDLINE | ID: mdl-31387992
The synaptotagmin (syt) proteins have been widely studied for their role in regulating fusion of intracellular vesicles with the plasma membrane. Here we report that syt-17, an unusual isoform of unknown function, plays no role in exocytosis, and instead plays multiple roles in intracellular membrane trafficking. Syt-17 is localized to the Golgi complex in hippocampal neurons, where it coordinates import of vesicles from the endoplasmic reticulum to support neurite outgrowth and facilitate axon regrowth after injury. Further, we discovered a second pool of syt-17 on early endosomes in neurites. Loss of syt-17 disrupts endocytic trafficking, resulting in the accumulation of excess postsynaptic AMPA receptors and defective synaptic plasticity. Two distinct pools of syt-17 thus control two crucial, independent membrane trafficking pathways in neurons. Function of syt-17 appears to be one mechanism by which neurons have specialized their secretory and endosomal systems to support the demands of synaptic communication over sprawling neurite arbors.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Endosomas / Neuritas / Transmisión Sináptica / Sinaptotagminas / Proyección Neuronal / Proteínas del Tejido Nervioso Límite: Animals Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Endosomas / Neuritas / Transmisión Sináptica / Sinaptotagminas / Proyección Neuronal / Proteínas del Tejido Nervioso Límite: Animals Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido